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Homo sapiens (human) HOX transcript antisense RNA (HOTAIR) URS000075C808_9606

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HOTAIR: HOTAIR is a long non-coding RNA (lncRNA) that has been found to play a significant role in promoting the growth and metastasis of melanoma [PMC5689618]. It has been shown that the murine HOTAIR promoter contains two putative HNF4α binding sites [PMC6461983]. HOTAIR has also been found to regulate oxaliplatin resistance in colorectal cancer (CRC) by sponging miR-1277-5p, providing insight into the mechanism by which HOTAIR mediates hypoxia-induced oxaliplatin resistance [PMC9263107]. Additionally, down-regulation of miR-152-3p can rescue the effects of HOTAIR silence on malignant melanoma progression [PMC8379738]. Aberrant overexpression of HOTAIR in the abdomen strongly suppresses adipogenesis through DNA methylation, histone modification, and transcriptional regulation of genes associated with nervous system development and lipid metabolism [PMC9034304]. It has also been shown that HOTAIR is involved in oxaliplatin and hypoxia-mediated epithelial-mesenchymal transition (EMT) signaling pathway [PMC9263107]. Knockdown of HOTAIR decreases luciferase activity and can be rescued by miR-152-3p inhibitor in melanoma cells [PMC5689618]. The role of HOTAIR in adipogenesis is independent from its epigenetic scaffold function during adipose differentiation [PMC9482196]. Furthermore, it has been suggested that HOTAIR may be involved in hypoxia-enhanced oxaliplatin chemoresistance and poor prognosis [PMC9263107].

mRNA interactions 1 total

Genome locations

Gene Ontology annotations

Sequence

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CCUCCAGGCCCUGCCUUCUGCCUGCACAUUCUGCCCUGAUUUCCGGAACCUGGAAGCCUAGGCAGGCAGUGGGGAACUCUGACUCGCCUGUGCUCUGGAGCUUGAUCCGAAAGCUUCCACAGUGAGGACUGCUCCGUGGGGGUAAGAGAGCACCAGGCACUGAGGCCUGGGAGUUCCACAGACCAACACCCCUGCUCCUGGCGGCUCCCACCCGGGACUUAGACCCUCAGGUCCCUAAUAUCCCGGAGGUGCUCUCAAUCAGAAAGGUCCUGCUCCGCUUCGCAGUGGAAUGGAACGGAUUUAGAAGCCUGCAGUAGGGGAGUGGGGAGUGGAGAGAGGGAGCCCAGAGUUACAGACGGCGGCGAGAGGAAGGAGGGGCGUCUUUAUUUUUUUAAGGCCCCAAAGAGUCUGAUGUUUACAAGACCAGAAAUGCCACGGCCGCGUCCUGGCAGAGAAAAGGCUGAAAUGGAGGACCGGCGCCUUCCUUAUAAGUAUGCACAUUGGCGAGAGAAGUGCUGCAACCUAAACCAGCAAUUACACCCAAGCUCGUUGGGGCCUAAGCCAGUACCGACCUGGUAGAAAAAGCAACCACGAAGCUAGAGAGAGAGCCAGAGGAGGGAAGAGAGCGCCAGACGAAGGUGAAAGCGAACCACGCAGAGAAAUGCAGGCAAGGGAGCAAGGCGGCAGUUCCCGGAACAAACGUGGCAGAGGGCAAGACGGGCACUCACAGACAGAGGUUUAUGUAUUUUUAUUUUUUAAAAUCUGAUUUGGUGUUCCAUGAGGAAAAGGGAAAAUCUAGGGAACGGGAGUACAGAGAGAAUAAUCCGGGUCCUAGCUCGCCACAUGAACGCCCAGAGAACGCUGGAAAAACCUGAGCGGGUGCCGGGGCAGCACCCGGCUCGGGUCAGCCACUGCCCCACACCGGGCCCACCAAGCCCCGCCCCUCGCGGCCACCGGGGCUUCCUUGCUCUUCUUAUCAUCUCCAUCUUUAUGAUGAGGCUUGUUAACAAGACCAGAGAGCUGGCCAAGCACCUCUAUCUCAGCCGCGCCCGCUCAGCCGAGCAGCGGUCGGUGGGGGGACUGGGAGGCGCUAAUUAAUUGAUUCCUUUGGACUGUAAAAUAUGGCGGCGUCUACACGGAACCCAUGGACUCAUAAACAAUAUAUCUGUUGGGCGUGAGUGCACUGUCUCUCAAAUAAUUUUUCCAUAGGCAAAUGUCAGAGGGUUCUGGAUUUUUAGUUGCUAAGGAAAGAUCCAAAUGGGACCAAUUUUAGGAGGCCCAAACAGAGUCCGUUCAGUGUCAGAAAAUGCUUCCCCAAAGGGGUUGGGAGUGUGUUUUGUUGGAAAAAAGCUUGGGUUAUAGGAAAGCCUUUCCCUGCUACUUGUGUAGACCCAGCCCAAUUUAAGAAUUACAAGGAAGCGAAGGGGUUGUGUAGGCCGGAAGCCUCUCUGUCCCGGCUGGAUGCAGGGGACUUGAGCUGCUCCGGAAUUUGAGAGGAACAUAGAAGCAAAGGUCCAGCCUUUGCUUCGUGCUGAUUCCUAGACUUAAGAUUCAAAAACAAAUUUUUAAAAGUGAAACCAGCCCUAGCCUUUGGAAGCUCUUGAAGGUUCAGCACCCACCCAGGAAUCCACCUGCCUGUUACACGCCUCUCCAAGACACAGUGGCACCGCUUUUCUAACUGGCAGCACAGAGCAACUCUAUAAUAUGCUUAUAUUAGGUCUAGAAGAAUGCAUCUUGAGACACAUGGGUAACCUAAUUAUAUAAUGCUUGUUCCAUACAGGAGUGAUUAUGCAGUGGGACCCUGCUGCAAACGGGACUUUGCACUCUAAAUAUAGACCCCAGCUUGGGACAAAAGUUGCAGUAGAAAAAUAGACAUAGGAGAACACUUAAAUAAGUGAUGCAUGUAGACACAGAAGGGGUAUUUAAAAGACAGAAAUAAUAGAAGUACAGAAGAACAGAAAAAAAAUCAGCAGAUGGAGAUUACCAUUCCCAAUGCCUGAACUUCCUCCUGCUAUUAAGAUUGCUAGAGAAUUGUGUCUUAAACAGUUCAUGAACCCAGAAGAAUGCAAUUUCAAUGUAUUUAGUACACACACAGUAUGUAUAUAAACACAACUCACAGAAUAUAUUUUCCAUACAUUGGGUAGGUAUGCACUUUGUGUAUAUAUAAUAAUGUAUUUUCCAUGCAGUUUUAAAAUGUAGAUAUAUUAAUAUCUGGAUGCAUUUUCUGUGCACUGGUUUUAUAUGCCUUAUGGAGUAUAUACUCACAUGUAGCUAAAUAGACUCAGGACUGCACAUUCCUUGUGUAGGUUGUGUGUGUGUGGUGGUUUUAUGCAUAAAUAAAGUUUUACAUGUGGUGAAUAUAAA

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Publications