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Homo sapiens (human) long intergenic non-protein coding RNA 2613 (LINC02613) URS000075B9E5_9606

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LINC02613: LINC02613 is a long non-coding RNA (lncRNA) that has been found to have significantly lower expression in tumor samples compared to normal samples [PMC9091017]. In a gene set enrichment analysis (GSEA), it was observed that low expression of LINC02613 was associated with enrichment of gene sets related to DNA replication, cell cycle, glycolysis gluconeogenesis, Wnt signaling pathway, antigen presentation, and chemokine signaling pathway [PMC9091017]. The relationship between LINC02613 and the Wnt2, Wnt3, and Wnt3a coding genes was investigated in a study [PMC9091017]. However, the study only explored the expression of LINC02613 on a bioinformatics platform due to objective constraints and acknowledged that it may not be sufficient for rigorous scientific study [PMC9091017]. Further analysis revealed that LINC02613 is related to immune response activation and primarily involved in cell cycle repression [PMC8202402]. In terms of prognosis, LINC02613 was identified as one of the five independent prognostic factors along with age, T stage, metastasis status, and ER status [PMC9091017]. Low expression of LINC02613 was found to be associated with positive expression of ER (54.9% vs. 31.6%), PR (58.2% vs. 38.8%), and HER2 (66.2% vs. 44.5%) in breast cancer patients [PMC9091017]. Overall, these findings suggest that LINC02613 may play a role in tumor development and progression through its involvement in various cellular processes such as DNA replication, cell cycle regulation, immune response activation, and hormone receptor expression in breast cancer patients [PMC9091017][PMC8202402].

Genome locations

Gene Ontology annotations

Sequence

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AGCUGUGUCCUGGCUCAGACGGACAGCUCUGACUCGCUCGCUCUUUCUCUGGGCGCCUGCGCGCCUACCAUGACAAGCCAUUUCAGGCGAGCCGAGCCCCAGAGCCAUGUGUCUGGUGCGCAGUGUUAACAGGGCAGUUAUACCUUUUACAGACAACUGUGGCUCCAAGUCAAGUAUGAACUUACACAAACAGUUUAUAUAACAAGUGGAGGUGUGCGCCUGCGUGCCAAACUUGCUGACUCGUGCAGGCCUGGAUACCCGCCUCAGACUAUUCCUUGACCGAAGCACUUCCAGGGCAGGAAACUGAAGCUCUUGGGAAGGUGGAAGUUGCACGUGGUCUCACAGUCAACUGUGCCAGAAUAGGAGGCCAGGAACCAUCUCUGCUGGAGGAAGACCCACCACGCAUCCCUUCAAGAAUGCCAAGGUCCAGAGCAAGUGCUUCCCUUCUAUGGGCACAGGAGGGCUGUGGGAGCCCACAGAAUGUGCUUCUGGCCAGAGUGGGAUCCCCGAGGAAGAUGUUAAGACCUCUAAUAAUAUUUAAGAGCAAAAUUAGCACAGCUCCAGCCCAUGGGCAAGUUAAGAGACAGGAGUAGUGUCUGUGGAGUGGAGGAAAGCAGAGGCUGCCGCUGACCAUCCUGCAGCCCUCGCUCUGGCUGCUCACAGCUCUCCACCUUCUCUGGACUUCGUCACUUCAGUAUGUGAAACAACCAUUUCAACCAGCUUGGACAAAAGAGAGAAGCCAAGAUGGGGCUGAGAAACCAAUGCAGGCAGGCCCAGGGACCCAGGAGUCAGGGACCAGGUGCUACCAGAUGCUUGCUCCGACUCGUGUUGCUGCUGUCUUCUCUGUGCCUCAACUCUGUCCUCUGUCACUGCAGGCAGCUUCCUCCCAAGGUGGAAGGUGAUAUAUCCCACCUCAUGAAAUCAGGCUUCACCACAAGAUUGCUUUGACCAAGGGGACGUGAGUAGAAGUUUGAAGAACCACAGACUGGUCCAUCACCUUGUUUCUUAUCCCUCUGACAUAAGCAAUGUCCCAGACUGGGGCUGUUCUGUUAGCCUGGCUUCCAGAAUGAAGAGAGCUGAUCUACAUGGCAUAUGUAAGAUAAAUAAACCUUUGUUAUUACAAACCACUGAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications