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hsa-mir-595: Hsa-mir-595 is a microRNA that is part of the TGFβ signaling pathway [PMC9319258]. In a study comparing different types of mesenchymal stem cells (MSCs), it was found that the expression of hsa-mir-595, along with hsa-miR-122-5p and hsa-miR-576-3p, was weakly altered in M-MSCs compared to AF-MSCs, but strongly upregulated in L-MSCs [PMC9319258]. Additionally, the analysis of miRNAs revealed that hsa-mir-595 was one of the five miRNAs that were downregulated in the study, along with hsa-miR-636, hsa-miR-939, hsa-miR-720, and hsa-miR-623 [PMC4222092]. On the other hand, eight miRNAs were found to be upregulated: hsa-miR-338-3p, hsa-miR-342-3p, hsa-miR-30b, has-miR30c, hsa-miR-27a, hsa-miR-27b, hsa-miR-374a, and hsa-miR-92a [PMC4222092]. These findings suggest that there are distinct expression patterns of miRNAs in different types of MSCs and that there may be specific roles for these miRNAs in regulating cellular processes [PMC9319258] [PMC4222092]. Further research is needed to fully understand the functional significance of these findings and their potential implications for MSC-based therapies.
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