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Homo sapiens (human) long intergenic non-protein coding RNA 2042 (LINC02042) URS000075B2BB_9606

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LINC02042: LINC02042 is a long non-coding RNA (lncRNA) that is significantly upregulated in esophageal squamous cell carcinoma (ESCC) tissues, cells, and plasma [PMC7060651]. It has been found to play a crucial role in the pathogenesis and progression of ESCC [PMC7060651]. LINC02042 has been shown to increase the stability of c-Myc mRNA, and its pro-tumor effect is dependent on c-Myc [PMC7060651]. High expression of LINC02042 is positively correlated with malignant features in ESCC patients, including larger tumor size, poor differentiation, advanced TNM stage, and lymph node metastasis [PMC7060651]. LINC02042 has also been found to be positively linked with c-Myc through a positive feedback loop that magnifies its pro-tumor effect in ESCC [PMC7060651]. It enhances the aggressive phenotype of ESCC cells and promotes cell proliferation and invasion both in vitro and in vivo [PMC7060651]. LINC02042 interacts with YBX1 to increase c-Myc mRNA stability via YBX1-dependent mechanisms [PMC7060651]. Furthermore, plasma LINC02042 has been identified as an excellent non-invasive diagnostic biomarker for patients with ESCC [PMC7060651]. The overexpression of LINC02042 is associated with poor prognosis in ESCC patients [PMC7060651]. However, further investigation is needed to confirm the clinical implications of LINC02042 on a larger scale and its role in other malignancies [PMC7060651].

Genome locations

Gene Ontology annotations

Sequence

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GUGAAGUCAUGAUACAGAUGGAGAAAUAGUCCCCCUGAGGUCUUGCGCACAGAUUUUAAGAUGAUUCUCACUUACAAGAACACUGAGUGGUUACCAACUGCCCAACAGAUACGUCAACUGCAAGAUGUUCUAUCAAGCAAUUCACUACUUCCUCCCUUCUCAAUCUUCAGGCUCUGCAUAUGGAAAUGAACAUUUCAUUAUGACCCUAUGACCUACAAAGCUCCCUCUCUGUCACUCCUUAUCAUCUUUCCUAGGGAGGCAAUCAAAAUGAAAUGAUUUUAAGAUUCUAGCACUCCCAACUCUAAGAUGAAAAUGAUGCAGCAAUCAUGAACUCCUGUGUUAUCUGUCACUAUCUCAUAAGUCACAUGAUUUGAAGAGAAGAUCAUUCGGAGCAGUGGAAAAAUGAAAUCAAACAUAGCUGCUACCUCAGAUUGAAGAGAUGUCCUCUCCGAUUCUUUAAAGUAUUUCCUAUUCUCCUACCCACCUCCUCUGUUGUUUGCAAGACUCAAAAAGAUAAAUUUAUAGUGAAAUAAGAAUCCUCCAACUUACAUAUUAGAGCUUCUGCAAUUAAAGAAAAACAGAAAUCAGGCUGGGCGCAGUGGCUCACGCCUGUAAUCCCAGCACUCUGGGAGGCCAAGGUGGGUGGAUCACCUGAGGUCAGGAGCUUGAGACCAGCCUGGCCAACAUGGCAAAACCCCAUCUUUACUAAAAAUACAAAAAUCAGCUGGGUGUGGUGGUGGGUGGCUGUAAUCCCAGCUAUUCAGGAGGCUGAGUCAGGAGAAUCCCUUGAACCCAGGAGGCAGAUGUUGCAGUGAGCCGAGAUGGCACCACUGCACUCCAGCCUGAGUGACAGAGUGAUACUCUGUCUCAAAAAGAAAAAAAGAAAAAGAGAAAUCUAUGGGUGAAGACAAAUGGAAUGGCAAUACCUUGGAGUAGCAUUUACUAAUUCAAGCCAUAUAAACCAUACUAAGGUUGUCAGCCCAGAGGGGAGUCCAUCUGCUAUGUAGAUGAGAGAAUGCGACCAGGAAAGUCAGGACACAAAGCCAUGAUUCUUUCAACUUUUUGGCACUUUAAUAAGUGAAUUGCAUGUCCUGUCUUCUCCAUGAACUCAGCAAAGCUACAACUAAGCUCCUCAUCUUGAGAGUUCACCAUGUGCCCACUUUGACCUAUGGAUGGGCCCCUUGGCACUCUACCUUUUCAGUGUCCUCAACUGCACAAACUUCCUGGGCUGCACUGACUGCUGUACCCAGGCAAUUUUUUGGGAGCUCCAAUGUCUUGUCUAGCACAUGACAUGAGGCUGUAGCAUGUUCUUUCAAGUAUUAGUGCUAAAGAGGUCCCAUUCUACUUUCUCUGACUGAUCAGGUCACUGUUUUCAGCUACCUGGCCCUUCUAAGUCAGGGUCACUAGAGUAUUGGGAGGUUUGUAACUUCUUCAUUGGUGUCUUGUGUUUUCCUGUCUUUGAACUUGAGGAAAGCUGGCCCUGGAUGUUCACAACAUCAACCAAGCAAUGAAAACCACAGCACCCUACAGGAAAUUCUGCAUUUCUCUCAAAACAUGCAAAACACAAAAUUGGGUGGAACCACAGAAGGUUAUGGAUAACUCACUACAGUUUGGACUUUCAAAGGCCCUGGGAAAACUAUCCUACUUUUGUGAGAUACUAUUGUUCUACCUGUAAUGCAAGUGAACAGAUCUUAAUAAGGACAAAUAACAAUUUUUUAAAUGUUUACCAUAUUUUCUCAUUUGUUCCUUUCAUCAAGCAUCCAACCUGCCAGACCCUGCACUUGAUGGAUCAGCUGGCACCACCCAAAUCAAUAAACCGGCUCAUCUGAUCUUGUGGCACCCACCCAAGAACUGACUCAGCACAAGGAGACAGCUUCGACUCCCUGUGAUUUCAUCCCUGUCAACCAGCACUCCUGGCUCACUGGCUUCCCCCCACCCAACCAAGUUAUCCUUAAAAACUCUGCUCCCUGAAUGCUCAGGGAGUUUGAUUUGAAUAAUAAUAAAACUCCAGUCUCCUGCAAAAAAAAAAAAAAAA

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Publications