SNHG8: SNHG8 is a long non-coding RNA (lncRNA) that has been implicated in various biological processes and diseases [PMC8973976]. It has been shown to promote melanoma cell proliferation, migration, and invasion through a ceRNA network involving miR-656 and SERBP1 [PMC8973976]. SNHG8 is expressed in adult human lenses [PMC7820909]. It also exerts an anti-apoptotic function in the process of hippocampal neuronal apoptosis [PMC6549185]. Knockdown of SNHG8 inhibits the progression of esophageal cancer [PMC8974072] and is associated with poor prognosis in gastric carcinoma patients [PMC6224255]. SNHG8 overexpression affects ischemic microglia through miR-449c-5p mimic abrogation [PMC9585453]. In cardiomyocytes, SNHG8 plays a significant role in myocardial cell injury caused by hypoxia, with knockdown providing protection and overexpression promoting injury [PMC7437243]. SNHG8 also plays a functional role in EBV-associated gastric cancer (EBVaGC) [PMC5924468] and colorectal cancer by sponging miR-663 [PMC8802510] and upregulating AP3D1 to promote progression [PMC8810013]. Knockdown of SNHG8 inhibits the proliferation and promotes the apoptosis of esophageal cancer cells [PMC8974072], while overexpression increases CCK-MB release, cTnI release, and mitochondria viability in myocardial cells [PMC7437243]. Higher expression levels of SNHG8 are associated with a later TNM stage in gastric cancer patients [PMC8144696], while patients with high levels have shorter overall survival [PMC8554152]. Examination of SNHG8 isoforms reveals ENST00000602414, ENST00000602483, and ENST00000602819 [PMC8416628], but it is not significantly upregulated compared to ZFAS1 or GAS5 in hepatocellular carcinoma tissues [PMC8199104]. Knockdown of SNHG8 promotes apoptosis in breast cancer cell lines [PMC8039051].