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Homo sapiens (human) long intergenic non-protein coding RNA 992 (LINC00992) URS000075B027_9606

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LINC00992: LINC00992 is a long non-coding RNA (lncRNA) that has been studied in relation to its effects on gene expression in breast cancer cells. In MCF7 and T47D cells, knockdown of LINC00992 resulted in downregulation of MYB and PDZK1 genes. However, this downregulation was reversed when wild-type GT3-INCP was overexpressed, but not when mutant GT3-INCP was overexpressed [PMC9974104]. LINC00992 has also been found to have a positive expression correlation with CYP2J2 (r = 0.29, Pearson’s correlation, p < 0.001), CYP1A1 (r = 0.21, Pearson’s correlation, p < 0.001), and other genes involved in the xenobiotic metabolism pathway [PMC6085336]. These findings suggest that LINC00992 may play a role in regulating gene expression and xenobiotic metabolism in breast cancer cells. Further research is needed to fully understand the mechanisms by which LINC00992 influences gene expression and its potential implications for breast cancer treatment [PMC9974104] [PMC6085336].

Genome locations

Gene Ontology annotations

Sequence

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AGCAUCUCUGCCAACUCUAGAGAGUUUAGAUAUCUACUUAUUUAUAUCUACAUCUAUCUAUAUUUAUAUUAAACAAAAGUGACAGGACAUGGUAAUAGAUGCAAUGUAUAGGUGAAUUAGAGAGAGGUAUCAAGCUUGACUCCCAGGUUUCUGAUAGAAUGGCUGAAUUGAUGGCAAUACCUUUCACUGAGAGGAAACAUUGGCAGAAAACCAGUUUUGAAUGAAGAGGAUGCUUCCUUUUCCUUCUGACAUGAGUGGAACCAGCCAUAGGCCCUCAUCAGAGGCAGAUGCUGGCACUUUGCUUCUCGUACAGCCUGCAGAAUGUUAAUACUCUUGGAUAAUGUAUUUAAGGAUGCUUAAGUUCAUCAUGGGUCCUCUGGAAAUCUCCUACCUUUGUGAGCAAAGAUUACUGCAGGGUGGAAGACAGGUCCAUGAUUGCCCAGGCUGCAGUGCAAGAAGUAUGAUGGCACCAUAUCUCAUCUUGCACCUCAAUGAUCAUCUAACAAGAAUCCUUCUGCAGAUCCCAUCUAAAAUUACAUUUCCAGGCAUUCCACAUAACCGGAGGAAAAAAAACAUGGAUCCUAUGGAAAGUAUUUGAAGAGUUUCAAAAAUAAGAAGAAAAAUAGCAGAACAGUAUGAGAAGACAGAUGGCUCAGCUGAUGACAAAAUCCAUUUGACUUUUACCACAUUGGGAGAUGGAGAGCUUGAUUAAUAGUUGGUCAGCCAAUGAGACAAUUUAACAAGAAAAGCUACUUGGCAAAAUAUGUCUUAACCAGAUACAGCUAUGUUAUAACUGUUAUAACUUAAAUGUUUCUUGUGGAAUCACCAUUUUGCAUCAGACCUCUUAAAUAUGCCUGUUUGAAUAAGCUCAAACCAACAUAAAACUGUUUCUAGCAUUAAGUCCACAACGUAAGCCAAUAUCAAUCUAUUUUAACUGCAUCUACUGAUUAGGUAAAAAAGAAAAUGCCAUUGAAAACUUCUUAGUGCCUUUCCCUGAAUGGCACUAUAAUCUAUUACAAUUACCAAAGAGAAAAAAGAUCAAAGAACGCCUGCCUAUACAAAUUAUUCUUAGAAUACUAGAACUUCAGAGUUGGAAAGAGCCUGAAACUUCUUCUAGCCAAUUACCUUUAUUUUACAACUGAAAUUAAUGAGGCGCAGACACAUGAAGUGACUUUGCUGAGACCACACAGACUUGGAGGAAAAACUAUGUGAGAACAUGAAUUUCUGGUCUUCUAAUUCAAUAUGCACUAUCUUUUUUUUUUUUCCAUUUUUUACUAUAUGCAUAGUCAGUUAUCUUAGAAAUGUUGUUAGGAUUAUUAUGGCUUCUUUUUUAAAGUUGGAGAGGACAUUGCCCAUUAAAUUACAUGUGCCUGUGCUUCAGAGUUAUCCAAGAUCGGAAAUUGUAUAUCUCAAAAUAAACAUGUGAAUAGCAUUUUUAAAAUGCUGUUUAAUAGAACAUAUCUCUUGUAAAAGCCUGGGGAUAACAUGAUAAUAUCUGUUAAUUUUAACUAGAUUAAUUUCUUUUUUUUUUUUUUUUUUGAGACGGAGCAUUGCUCUAUCGCCCAGGCUGUAGUGCAGUGGAAUGAUCUCGGCUCAUCUGGGCUCACUGCAAGCUCCACCUCCAGGGUUGACGCCAUUCUCCUACCUCAGCCUCCUGAGUAGCUAGGACUACAGGCGCCCGCCACCACGCCCAGCUAAUUGUUUGUAUUUUUUAGUAGAGACGGGGUUUCACCAUGUUAGCCAGGAUGGUCUCCAUCUCCUGACUUCGUGAUCCACCCGCCUCGGCCUCCCAAAGUGCUGGGAUUACAGGCGUGAGCCACCGCACCCGGCCUUAACUGGAUUAAUUUCUAAAUAAUAAUUUGGAAGGGGGGAUAAUUUUUAUAUCAUUGAUUUACUUGUUAUUAUUGACCAGAUUUUUGGUAACCUUUAGUUUUGUGAACCCAUCAUAAUAUUAUAAGGAAAAUAGCCAAGAGGAGCAAUGACUUUAGAGCAGAUGACCCCUUGAGCUAAACCUUUCAAGGGAAAUAAAUCACAAAAAAAAUUAUAGCAACUUUAGCUUCAACUUGAGAAUACAUGCUCAAAAUAUUAUGGCUGUGGUUAUUACACAAUGAUAUAUUAUGUGAGUGAUUUCCUAGGGAACCUUCUCUUCAUCUUGUUAUUAUUUUUUGACCAUACUGGUUUAUUUAUACAAUUUUAUACUAGAUGCUUCUCUCAUUUCCUUGAUAACACAGCUGCACACACACACACACAAAUGUCUGUCUAUUGCUGAACAAUGUUAAGUAAUAUAAUUUGACACAUGUACAUUGCAAAUCAAUAAAUGUGACAUUUUCUUUUCCUGGUACAUUCUGUAUAACUUAUAACACAGCUUCGGGUAUAUGAUAUGCCAAGUCAUAUCUUCUGUAUUAUAUCAACUGAAUAAAGGAAAAGGCUGAUAUAAUUUAAUUUCUUAGGGUAGAUUACUUUUGUCUCCACUUAAAAACUGCCUCUCAUGUUUUGAAUUAAAAGUUGUUUGUCAAAUUGGAUAUACCAAAUCAUUGCAUUCCUAGCUGUCUAUAUUAAAGACAUUUAAACAUUGUAUAUAUAAUUACUACAUAUACAUUAAUAAUAUAUAAUGUAUGUAUACACAUCAUAUAUAUAAUUAAUAUGAGAGAAACCGUUGAUCAUCUUUUUAUAGUCCCUAGACUGUGACAAAAAAUGUUAAAUAUAUAUUUUCUGAGUGUAUAUCUAAUAGUCACAUGAAUGUGACAUACUCCAUAAGUCAUCAAAUGAUAGUAUUGUUUUGUGAUUUUUUACUGUAUGUAAAGUUAUCACUUCCAAAAAAAUCUGCAUAAUAUUAUUGAAUUCUAGUUGAUCCAAUGCAUGCAGAAAUAUUUGGAGGUAAAUUGUACUAAUUUAAGCAAACUUUUUAAAAAUUCAUCAAAGUAAACAUGGAUGUAAAUAUAGACAGAGAGUUGCAUAGACGGAUAUGUGAUAAAGCAAAUAUAACCAAAUAAUAAUGUAGAAUUUAUAAAAUCAGUAAAUGGGUGUUAAUUGCACUAUUAUUUUGAUAUGUCUGUAUAGUUGAAAUUUACAUAAAAAUACUGGAAAAACA

Taxonomic tree

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Publications