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Homo sapiens (human) long intergenic non-protein coding RNA 518 (LINC00518) URS000075AEC3_9606

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LINC00518: LINC00518 is a long non-coding RNA (lncRNA) that has been found to play a significant role in the malignant progression of melanoma [PMC6848151]. In a xenograft mouse model, the effect of LINC00518 in LUAD cells was confirmed, demonstrating its importance in vivo [PMC8897435]. LINC00518 was found to promote melanoma cell proliferation, migration, and invasion by regulating EIF4A3-mediated mRNA stability of MITF [PMC9262545]. Additionally, it was observed that LINC00518 facilitated the migration, invasion, and metastasis of melanoma through the miR-204-5p/AP1S2 axes [PMC9653531]. This finding is consistent with previous reports that have identified LINC00518 as an upregulated lncRNA in various malignant tumors [PMC6848151]. Furthermore, through analysis of shared transcripts obtained from different approaches, it was determined that LINC00518 exhibited a positive correlation with certain mRNAs and a negative correlation with miRNAs potentially sponged by the lncRNA [PMC7767460]. Additionally, due to its location and strong coexpression with TFAP2A, it is suggested that LINC00518 may act in cis by regulating the expression of its neighboring genes [PMC5970542]. Moreover, interference or silencing of LINC00518 has been shown to suppress proliferation, clone-formation ability, migration, invasion of A549 cells and inhibit tumor growth both in vitro and in vivo. Furthermore silencing increased ADR-mediated anti-tumor effect. Overall these findings highlight the significant role played by LINC00518 in melanoma progression and suggest its potential as a therapeutic target for this disease.

Genome locations

Gene Ontology annotations

Sequence

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AGUCCUCAGAGAGUCCUCUCUCUCGGCAUGGACACAAAAGAAAAGCCAUGUGAGGACACAGAGAGAAGGUGGCUGUCUACGAGCUAGGAAGAAAGGCCUCACCGGAAACCAACCCUCACAGCAGCUCCAUCUUGGACUUCCAGCCUCCGGAACUGUGAGAAAAUAAAUGUUUGCAAUUCAGGUCGGUUGUAUUUUGUGAAGGCCAUCCUAGCAAAUGAAUACUCCUAACAUUGUCUCUUUAAGAGCUCACCAGCCUGAGGUAGGAAUCAUUCCAUCUGUGUUACUAAUGAGACCGCUGAGGAUCAAAGGGGUUUUCCACCACAUCCACUCACCUCUACAUGGCGAAAACCAAGGGUUCACUCUCUGUCUUCAGGGAGCUCCACCCAGCAGCAGCGUUUGACAGAGCUGUUCACUUCCUCUUCCUGGAGCUGUGGCUUCCAGAGCCCAUGCUCAGCAGUUCCCCUCCUUCUUCGACUGCUCCUCUCUUAGGCUCAGAGCCACUCAGACAUUGGGAAGCAAGUUUGUCAAGAUGACAGAGAACCGAGGUAAUGGAUUCGAGUGAUGAAACAGGAAGUUCAUUCAUGAGUUUUUGGCCACACCUCCAAAGUGACGACUUAGCCAGAAAUGGGAUAACUGGGUUUCCCUACUUCUCUUUUAUCAUCCUCAAUGAGAGUGACCAAAUAUUAGAGCUAGAUGGAACCUUAGUGAAAAUCUGGCUACUCGUCCCGUCCCACCAGCCUGCCACCCAUUUCAAGUUUGAAGAGACAAAGACACAUGGACCUUAUGUAAUUACUGGGGAUUACCCCAGGAGUCUGUGGCAAAAGUCAGCUUCUUCCCUCCCUGCUUCCCCGCCCUGUCUCUGGUACUUUCUACCAACACUGGGCUGUUUCUGUGAUCACACUUAAGCGUACCUAACCUGCGAAUGCUGUAUAGAAGGUGCUAAUGAACAUGAUUUAGCUUUAACACUCAGUUUUCUAAAGGGACACGUGGGGGCAGCAAAUGUUUAGGCAAAAACAAUUCCAGUUCUAGCCUCUACUGUCUACAUAUGUGUAUACAUUUGGGAAACGUUUGGGAAAGGGAUAUUUGAGAGCUUCUUUUUCUUUUUUGUGGUUUAGUUAUUUGAUGAUAUUGAGAUUGUUUCUGAGCCAUGUGCUUCAACAUCGGAUUGGGGAUUUCAGAAAAAGUUUUAGUCACUGUGAUUCCAUUUAGCUUCCAAAUGUGUCUCUGCUAAGAGACUUAAAAGCACUCAUAAAUAGCACGUGUGUCUUCUUUGCAGUGUUUGCUAAUUUUGAGUCACAUCUUUUUAGAAAAUCAUGAGAUUUGGUGUCACAGAGACUGGAAUAAAUAUAGUCAAACUUAUUGGUGAAGAUUUCCUUUAGCUGUUUUCAUAAUCCAUUUCCAUUGUUAUGAUUAUUGAUGAAUAAAACAUUUUCUUUAGGUAGAUACUUCUUUUUUCCCCCCACCUUGAUUUAAUGUUUCCACUCUUAUUGUCAAGUUUCUUAUUACUCCCUAAUAACUCUCAAUAAAAUAAUGAUUCCUGGGAGAUUAUUCCUGCUUUCCUACUAUCACCUGUUGAUUUGAAAAGACAGAACAAUACCGUAGAAGCUUCACUAAUACAUUGAAAGAUAAAAUGAUAAUACUAAAUACUAAAAUAUGAAAAGUGAUACUAAAAGUGGAGUCCUGGCACUAGUAUUUUUUUUUUUGAGUCUUUAAAUUUUAUUUAUUUAUUUUUGAAUUUUUUAAAAUUAUAUGUUAUGUUCUGGGAUACAUGUGCAGAACGUGCAGGUUUGUUACAUAGGUAUACAGGUCUGGCACUAGUAUUUUGUUGCCACAAAAUAUCAAGCAUGUAUCCAAACUGCUCAAGACACAUUAAAGACACAGGUAAUCUGUAGGCAUAUUCAGGCUUGUAGUUUGCAUUUUUUGGUUUUCUUGUGGCUUUCAGUGCAAGUUGAGGUAAUUCAUGGGAAACAGUCACCAAAGAAGUGCCAGUAUUAGAAAUCCAAGAGCCAUUUCUCUAGCUUCUUCCAGAAUCAAGACUUUAGAGGUAAUUUCUAUCAACACUGGACAUUUCCUGUCUGCAAUUAACAAUGAACACAUAGCAUUAUGUUUAAUUGCAACCUGUUUAAAGCAGAUUGGAUGCUAAGGUUUAAGAACACUCUUCAGUCAAAAAGGUCUUUUAAUCAGGUUUUUAAUCUUGAGCACAAUCUAGGACACAGCAUCAUAGACUAACUCAUUCGAGAAUAGGUGUUGUCAUCUAAUCCUAACCACCCCCACCACCAACAAGCUGAAUAGCUCUGGGCUCAGUAUAUACAUUUGUACUGGGCUCAGUACACACACCUAAGCUGGGUUCAGUAUAUGCCACUUUAUAGUGAGAGGCAUUUUGUAAUGAGAGCUCUGGGUUCACUAUAUACAUUUGUACUGGGCUCAGUACACACAUCUAAGCUGGGUUCAGUAUAUGCCACUUUAUAGUGAGGGCCAUUUUGUAAUGAGAGCUCUAAGGCUCUAAAAUUCUGUGUUUCUGCUAGUUUCUUCCUCAAGAUAAAACUGUGGAACUCAUAGUGAAUUCCCUCUCUUUGGGCAGUUUGAGCCAGGCCGCUAUUUAAUCACAACAUCACAAGUCAGAUUUUUCCUACCUAGUGUUGGCAGUGGAACACACCAGAACUGCUAAGGCCAAGGAAAUCCCAUUUUUUGAAGAGGCUUUCCUUUGUUAGCUUCUCUUUCUAGUAGUAAAGGUAAAAGAAAAAUAGAUGUUAAAGAUAUAAAUAUCUUAGGGGGUUUUUAUUGGUAUAAAUAUUUGUACACAAAAAGAAUAUGUAAUGUAAACUGGAUAUGUAUUUUUUACAUUUUACUUAACCUGAAUUUUACACAAUCUUUGCUUGAAUGCUCCAACAAUGAAAGGAGAAAAUAUGUAUUUAAACAAUUUUUAAGUAUUUAUUCUUUAUUCAGGACACUUGAGUUUCAUUCAAGCUAUAGUUUUAAAAUGUAAAAAUGCUGAGAAAUUAAAAGCAGUCAAAUGCU

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Publications