hsa-mir-4534: Hsa-mir-4534 is identified as an upstream regulatory miRNA and is associated with worse survival in breast cancer [PMC9906202]. It is suggested that hsa-mir-4534 may be a potential upstream miRNA of ADAMDEC1 [PMC9906202]. The correlation between hsa-mir-4534 and immune cells was investigated, and it was found that hsa-mir-4534 exhibits differential expression in normal and malignant human β cells, although its function is not clear [PMC9906202]. Hsa-mir-4534 was found to be associated with poor overall survival in breast cancer patients [PMC9906202]. There is a negative correlation between ADAMDEC1 and hsa-mir-4534, as well as a negative correlation between hsa-mir-4534 and most immune cell gene markers [PMC9906202]. The lncRNA TUG1 was found to be positively linked to ADAMDEC1 and negatively associated with hsa-mir-4534, suggesting it may be the most likely upstream lncRNA of ADAMDEC1 and hsa-mir-4534 [PMC9906202]. Hsa-miR-22-3p, hsa-miR-3202, hsa-miR-32-3p, and hsa-mir-4534 were identified as miRNAs that regulate the greatest number of genes [PMC7543140]. HSA-MIR 32 3p was downregulated in osteoporotic samples compared to osteoarthritic samples, while other miRNAs including HSA-MIR 22 3p were upregulated in osteoporotic samples compared to osteoarthritic samples [PMC7543140]. HSA-MIR 32 3p was also identified as one of the central genes in the PPI network along with HSA-MIR 4534 [PMC9532506]. TaqMan probes for hsa-mir-4534 were used in experimental studies [PMC5356562].

MIR4534: MIR4534 is a miRNA that has limited studies in pancreatic cancer [PMC10057657]. It has been identified as a differentially expressed miRNA in the transition from normal to tumor and tumor to F1 models [PMC10057657]. One study suggested that MIR4534 may play a role in prostate cancer through the regulation of PTEN [PMC10057657]. In CCD-18Co cells transfected with MIR4534 mimic, the relative expression levels of ACTA2 and CXCL12 mRNA were higher compared to cells transfected with miR control [PMC8484348]. Additionally, the autophagy of CCD-18Co cells transfected with MIR4534 mimic was more suppressed compared to cells transfected with miR control [PMC8484348]. Further investigation is warranted for MIR4534 and its potential role in pancreatic cancer progression.