cfa-mir-582: Cfa-mir-582 is a microRNA that has been studied in the context of canine myxomatous mitral valve disease (MMVD). In several studies, the expression of cfa-mir-582 has been found to be downregulated in dogs with MMVD, specifically in stages B1/B2 or C/D, compared to normal dogs [PMC5533140] [PMC9607079] [PMC4964495]. Additionally, cfa-mir-582 expression was found to be higher in dogs with more advanced stages of MMVD (C/D) compared to earlier stages (B1/B2) [PMC9607079]. In dogs with MMVD and mild to moderate cardiac enlargement or congestive heart failure, cfa-mir-582 was one of the seven downregulated miRNAs compared to normal dogs [PMC4964495]. Furthermore, cfa-mir-582 expression was significantly different between stages B1/B2 and C/D [PMC4490541]. Overall, these studies suggest that cfa-mir-582 may play a role in the progression and severity of MMVD in dogs. However, further research is needed to fully understand its specific functions and mechanisms.