hsa-mir-4274: Hsa-mir-4274 is an intragenic microRNA encoded by the second intron of the SORCS2 gene [PMC6857517]. It has been detected to interact with the LAMA4 gene in a PAR-CLIP experiment [PMC6857517]. The expression of SORCS2 mRNA is highly restricted to the nervous system and kidneys, and it is speculated that the relatively high levels of SORCS2 expression observed in basal-like breast carcinomas may be attributed to hsa-mir-4274 [PMC6857517]. Hsa-mir-4274 has been identified as a potential biomarker for idiopathic normal pressure hydrocephalus (iNPH) and has diagnostic potential as well as the ability to predict response to shunt treatment [PMC8966745]. It has also been found to be differentially expressed in breast cancer, with overexpression of hsa-mir-4274 associated with worse overall survival [PMC7523764]. However, hsa-mir-4274 levels were not affected by hydrocephalus and were significantly decreased in patients with Parkinson's syndrome (PS) compared to iNPH patients [PMC5240577]. Hsa-mir-4274 may be a useful biomarker for differentiating PS from iNPH patients and for predicting shunt treatment responses [PMC5240577]. Further studies are needed to confirm its differential expression in PS and iNPH patients and its relationship with patient responses to shunting [PMC5240577]. Transient transfections using mimics and inhibitors of hsa-miR-3679-3p and hsa-mir-4274 were performed in cell culture experiments [PMC5428869].