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Homo sapiens (human) Prader Willi/Angelman region RNA 1 (PWAR1) URS0000759FB4_9606

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PWAR1: PWAR1 is a gene recently identified in human iPSCs, and it is associated with the UBE3A-ATS lncRNA and two boundary elements (Martins-Taylor et al., 2014; Hsiao et al., 2019) [PMC8573313]. There is a single nucleotide variant (SNV) located downstream of rs4906947, between PWAR1 and SNORD115, and close to the SNORD116 locus [PMC9858946]. The target accessibility sites for different isolates of P. westermani, F. buski, and F.gigantica were identified to have a phylogenetic trend with preferences for interior loop, bulge loop, multiple branch loop, hairpin loop, and exterior loop [PMC3082855]. Specific primers were designed to target the 3'-terminal position of the ITS2 sequences in PWAR1, F. buski, and F.gigantica for species specificity evaluation using PCR with primer 3S [PMC3082855]. A patient was found to have a smaller deletion involving SNHG14, SNORD116, IPW, PWAR1, and SNORD115 genes [PMC9266595]. This deletion was atypical but included PWAR1 among other genes [PMC9266595].

Genome locations

Gene Ontology annotations

Sequence

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CACAAGGCUAUGUUCAUGCACUACUUCGGUAUAAUCUCAAAAUAAUUGCCAGCUCCCCAGUGGAACGCCUGCCUUGGUCCAUGUGGAAUGUGGGCAUAUGGUAGGAUUUCCUUGGAGGAACUAGAAGAGGAACAUAAAGAAUGUUAGGCAUAUAAAUUAUUGUUUCUUUUUCUUCUUGUUUCUUUCCACUGAGUUAUGUGUGAGCCCCCACACCCACCCUACCUUCCUGUCCUCUACCUUACUGAUGCUAUUUUCAGGCUGUUGUAGAAUUGGGUGUGUAAAAUUAAAUUAGCCUUUCUCCUCUUAAUAUCUGUAAAAUGAACAAAUUUGACAAAGAAACUACCUAUCUGAUAUAUAAGAAGGUUAUUAGCCUGUACCACAAGUGAAAAAGUUUCAUCCUGAUAUAUCAAAAUAGUACCACUUGAAGGAAAACGUUGGGGCCAUCUGUUUCUCUCAUUGUAGUUAGAGUACAGAUUUUUAAAAUAUGAGCCUCAGGCAUAAAAAUGCAGUAUUAGCAACUCAACUUGAAGAAGCAGUUACUAGUGUCCUGGGUGGGCCCCAGGGAAAAUAGUACCAACUGCCUGUUAUAUUUAACUGCAAUUAAAAAUGGCAGUGCUGGGUAUCUUCUGUCUCUGGGUCAUCUCCUAAAGAUCCUGCAGAGGGAGCCAUAGCUAGUGUAGAGGCCAGCCAUAACUAGCCAUGGCAAAGACCACAGGGAACGCUCUUCAACAUGCUCUGCACUGAUCCUCUACCCUGGUGUGGAGAAAUGUCAGAUUCAUCACUAACAAGGUUAAAGGUGUAAAUUGAGGGAAAAAAAUGAGAAAAGUUAUCUUUCACAUAAGACUUCAGAAAGAAAUUGCGUCGUCAGGUUUGGAACUGGUUUGUAAUUUCAUCCAGUUAUUUUCAUUUUAAUUACUGUCACUGUUUUCUUCAUCCUUGAUAAACUAUGAGCUCUUUGAGAUUGUCUUUUUCAUAUCCUGAUGUCAGAGCUUCCUGUAUUUUCUGAUCAUGGUAUGUGCUAAGUAAAUGCAAUUUUUAGCAUUUUGAAUGGUUUAUCAAAUGAUUGAAGGAGUGGGUAAUAAUAUAGAUUACAUAUACAGUCAGCCACAUAUGUGUAUGUAUGUGUAUUUGUGUGUGUGUGUGUAUAUGUAUAUACUGUUGACCCUCCGUAUCAAUGGGUUUCACAUUUGUGGAUUCAUCCAAUCAUGGAUCAAAAAUAUUCUUUAAAAAUAUGGUUGCAUCUGUACUGAACAGGCACAAACUUUUUUUCUUAUCAUUAUUCCCUAAACAAUGCAGUAUGACAACUAUUUAUCAUAGCAUUGACACUGCAUUAGAUAUGAUAAGUAAUCUAGAGAUUAAAGUAUAUAGGAGGAUGCAUGUGGAUCAUAUGCAAAUAAUACACUACAUCUUAUAUAAGGGACUUGAACAUCCAUGGAGUUUGGUAUGUGGUGGGUGAUACCUCCUCUUUGAGGAGGUGAGUAUCAGAGACGCAGGUAAAUAUGAUCCAGAGGGCAAAGAGGCAUUGCCAGCCUCACACUGGCUGUCAACACCAUGCUGAGUUCCACGAAAGCAGCGAGGAGAGGGUGGUGUUCUUGUUUCUGGUACAAUACCUGGCAUAGAGAAGAUGUCACAGCAAUGUUCGUCUAUUGAAUAAGUCACCAAAAUUGUGAAUGACUGAAUAAAUGGGCAAAGGGAUUUGUUCCCUACUUGCUGUGGGAAGUUUCUUGUAGUUAUGACCUCCAUGAAAGAGAGACUCGUAUCUGGAGAAAGUUCAUAGCUGAAACCAUGAGAUUUAACUUUUGAAGUUAUAAUGGAUCUAUUUUUUUAACAUCAUAAAUGAAGAUUAUGCAAUACUGUAUGUGCUUCAAUUGACACAACCCCUUCCCAUUCAGGGCUGAUUUAUGUUCUGUACUGAAUGACAGGCACAGAAGUAAAUGUGAUAAUCCUGUCCCGUCGUUACCCUUUAUUGUGGUCUUGCUGUGUCCCAGCCACACACUUCAUACUGUAUCUGUGUCAUCAUUCUCAUAUACAUCUAUAUAGGUACACUUCCAUAGACUUAGGCCCAUUUAAUGGAGGAGCAACUCCAACAUUUAGAGAUCAUGAAAGGUACCUCAUGACAUAUAUUGACCUAGUGGCAGAGCUGCUUAGUUCUACAGCCUCUGAGUGGAAUCCUCACGACAGUAAAAACACAAGCUUGGUUUCUCACACACUCUACCUGCUUUUUCUCAUCCCCUUUAGUCUCUAUUCCUUGCUGAGAUGUGUUAGGCAUUAAAUGGUUACAGUCUACUUCUGUGUGUAGUCUCCAAACACUCAGAAACCUCAAAAUUUAAAAAAAUACAGAACAAUAUGUUAUUAAAUAAUCAGGGACAAGUUAAAAUGGUAAAGAGAAUAGGCCACUUUGUGAAAUCAUAU

Taxonomic tree

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Publications