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hsa-mir-4262: Hsa-mir-4262 is a microRNA that is involved in the regulation of gene expression. It has been found to bind to several circular RNAs, such as has_circ_0067735 and has_circ_0070186, which in turn regulate the expression of target genes CACNA2D2 and IGF1, respectively [PMC7775584]. Through the construction of a competing endogenous RNA (ceRNA) network, several key interactions involving hsa-mir-4262 were identified, including its binding to NEURL1B in conjunction with INTS6-AS1 [PMC8485137]. Additionally, hsa-mir-4262 was found to be associated with changes in neuro-inflammatory markers and the regulation of neuro-inflammatory pathways and microglial activity [PMC9781133]. Furthermore, following treatment with nilotinib, hsa-mir-4262 was found to be significantly altered along with other miRNAs that interact with genes associated with neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic Lateral Sclerosis (ALS), and Huntington's disease (HD) [PMC9781133]. Hsa-mir-4262 was also identified in amplified loci of SIMA neurospheres and expressed in human melanoma cell lines [PMC4231109] [PMC8012736]. Moreover, hsa-mir-4262 has been implicated in various diseases including SARS-CoV-2 infection and type 1 diabetes (T1D) [PMC9259025].
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Gene Ontology annotations
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