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Homo sapiens (human) TPT1 antisense RNA 1 (TPT1-AS1) URS0000759A07_9606

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TPT1-AS1: TPT1-AS1 is a long non-coding RNA (lncRNA) that has been implicated in various cellular processes and diseases. Knocking down CDK16 reversed the inhibitory effect of TPT1-AS1 overexpression on cell cycle-associated proteins in thermally injured human dermal fibroblasts (HDFs) [PMC8210258]. TPT1-AS1 expression levels and the expression of miR-26a/HMGA1 were compared between KYSE180 cells, normal cells, and two other cell types [PMC9938642]. Genome-wide analysis suggests that TPT1-AS1 may be associated with liver metastasis in colorectal cancer [PMC7185097]. In vitro assays were conducted to investigate the potential function of TPT1-AS1 [PMC7185097]. The enrichment of TPT1-AS1 pulled down by NF90 antibody was significantly higher compared to IgG, indicating a potential interaction between NF90 and TPT1-AS1 [PMC7185097]. Furthermore, overexpression of TPT1-AS in SW480 cells led to an upregulation of VEGFA expression, while its downregulation in HCT116 cells resulted in a decrease in VEGFA expression [PMC7185097]. In summary, TPT2-ASL is an lncRNA that has been shown to have an impact on cell cycle-associated proteins when overexpressed. Its expression levels have been compared between different cell types. It has also been implicated in liver metastasis in colorectal cancer and its potential function has been investigated through various assays. Additionally, there is evidence suggesting an interaction between NF90 and TPT2-ASL. Furthermore, the expression levels of VEGFA were found to be influenced by the overexpression or downregulation of TPT2-ASL.

Genome locations

Gene Ontology annotations

Sequence

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GAGGCGGAGACACAAGGCUCCGUUCCACUGGGCACGCCAGCGGUAGAGACAGGGUUUCACCAUGUUGGCCAGGCUGGUCUCAAACUCCUGAGCUCAGGCGAUCUGCCCGCCUCGGCCUCCCAAAGUGCUGGGAUUACGGGCGUGAGCCACUGCACCCGGUUCAAGCGAUUCUCCUGCCUCAGCCCCCUGAGUAGCUGGGAUUACAGGCACGCGCCACCACUCCCAGAUCUUCACUUCAGGUCAGCUCCAAGGAGGCUAUCCUUGCCCAUCUUCCUAAAAUAGAGCUCUCAAAACCUGGCUGUUUUCCUUCAGAGCACUGGCCUCCAAUUGCUCCGGUAGAUUGCAAAUGACCUGCUUUCUUUCUGUUCCCGGGCGUUUGGACCCCUGUCUUGGACCGCUGUCGGAUAGUAAAUCCCAAGUAAGGUACCUGCCGUCGGCAGAUUUGAGCUUUCUUCUUGGACACCUAAUACCCAGAGUCCUCCAGGCUCCGGUAGAUUGCAAAUGACCUGCUUUCUUUCUGUUCCCGGGCGGCAUCGGACCCGUCGGAGAGUAAAUCCCAAGUAAGGUACCUGCCGUUGGCAGAUUUGAGCUUUCUUCUUGGACACCUAAUACCCACAGUCCUCCAGGCUCCGGUAGAUUGCAAAUGACCUGCUUUCUUUCUGUUCCCGGGUGGCAUCGACCCGUCGGAGAGUAAAUCCCAAGUAAGGUACCUGCCGUUGGCAGAUUUGAGCUUUCUUCUUGGACACCUAAUACCCACAGUCCUCCAGUAAAUCCCAAGCAAGGUACCUGCCGUCAGCAGAUUUGAGCUUUCUUCUUGGACACCUAAUACCCACAGUCCUCCAGGCUCCGGUAGAUUGCAAAUGACCUGCUUUCUUUCUGUUCCCGGGCUGCGUUCGGACCCCUGUCGGAUAGUAACUCCCAAGUAAGGUACCUGCCGUCGGCAGAUUGGAGCUUUCUUCUUGGAGACCUAAUACCCACAGUCCUCCAGAAAAACAAACAAAGACAUGGAUUUACUGUGCAUAUUAGCAGAUCCAUACUGGAAAAUGCAUGGAGGUUUCAUAUACACCACUUACAGUUUUCAGCUCCUCAGUAGUGACAAAGCCAUACCCAUCAUUGUCGAUUCGAUCAACAAUCUUCCCUAGCCUCUCCUUGCUCUCGUCCGGGGUGAGCUCGUCGAAGUUCUUGGAGUCCUCCUUGCCCAGGAAGGCCUCGUGGUCGUACUGGAAGCUCUGGUUGUCCUCAGGGGGCCGCUCGCCCAGCUCCGAGUCGGGCCGCACCACGCGCUCUUUGCGCACCGUGGGCUUGGCCCGCAGAACCCGCGGCGCCAGCACCAGCGCCAGCAGCAGCCCCAGGGCUAACCCCAGGCGGCCACCGCGCGCCAUCGUCCCGAGGAGAGGGCGGCCGGGAGGGAGACGCUGAGCGAGCGACAACAGCGGCAGCUCGGGAAUGGGGGCUCGGAGCGCGGCGGCCAAGUUUUAUGUUAUGUAUAUUUUACAAGUAAAAAAAUUUUUUCACCUCAGCCUGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

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Publications