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hsa-mir-936: Hsa-mir-936 is a microRNA that has been found to be upregulated in cases of follicle atresia, a process in which follicles undergo degeneration and cell death [PMC6256094]. It has been cloned into a lentiviral vector to generate a lentivirus construct [PMC7011958]. Cox proportional hazard analysis has shown that hsa-mir-936 is associated with a poor prognosis [PMC7139587]. It targets down-regulatory genes involved in alternative splicing, DNA-binding, mRNA transportation, and signaling [PMC7139587]. Hsa-mir-936 is part of cluster 2, which consists of down-regulated and up-regulated miRNAs in triple-negative breast cancer patients [PMC7139587]. It has also been found to have important regulatory mechanisms [PMC4222264]. The mature sequence of hsa-mir-936 is 5'-ACAGUAGAGGGAGGAAUCGCAG-3' [PMC6097652]. Hsa-mir-936 is not found in the genome of CHO-K1 cells or any other Chinese hamster miRNAs included in miRBase 20 [PMC4139590]. In follicles, hsa-mir-936 expression increases during follicle atresia, while it decreases during the healthy and pre-atretic stages [PMC9783981]. Hsa-mir-936 is part of a miRNA‒mRNA network involved in regulatory mechanisms [PMC9676937]. In prostate cancer cells, hsa-mir-936 is the most differentially expressed miRNA and can be neutralized using synthetic oligonucleotides or plasmid vectors for transfection experiments [PMC9556567]. Hsa-miR-601 has been identified as a prognostic marker and potential tumor-suppressor in breast cancer[ PMC7901788].
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