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MIR573: MIR573 is a microRNA that has been studied in various contexts. In breast cancer (BRCA), it was found that the gene GSDMC was significantly negatively associated with MIR573 and positively linked to MIR548AO [PMC9428000]. In a study of neuroblastoma (NB), genes correlated positively with MIR573 expression were found to be enriched for miR-573 targets [PMC8017594]. MIR573, along with MIR873, was identified as a candidate "MRE-code" miRNA in NB, suggesting its essential role in nucleocytoplasmic transport regulation [PMC8017594]. The expression of the MIR573 precursor was found to be higher in certain stages and types of tumors [PMC8017594]. In acute myeloid leukemia (AML), the gene MIR573 was identified as one of the prognostic genes associated with epithelial-mesenchymal transition (EMT) [PMC9568336]. The role of MIR573 in EMT is still controversial, as it has been shown to both inhibit and associate with EMT in different cancer types [PMC9568336]. Additionally, it has been demonstrated that TF ETS1 can activate MIR573 and negatively regulate the gene ERRFI1 [PMC8197996]. Furthermore, high-throughput sequencing revealed differential expression of several microRNAs, including upregulation of MIR573, when mesenchymal stem cells were co-cultured with human pulmonary arterial endothelial cells [PMC7675022].
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