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Homo sapiens (human) microRNA hsa-mir-765 precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-765 precursor URS000068E793_9606

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MIR765: MIR765 is a miRNA gene that has been found to be down-regulated in CNS tumor samples [PMC8235499]. It is one of five miRNAs, along with MIR149, MIR214, MIR574, and MIR595, that were consistently down-regulated across all CNS tumor samples [PMC8235499]. These miRNAs have been identified as potential diagnostic markers for CNS tumors [PMC8235499]. In addition to its role in CNS tumors, MIR765 has also been implicated in other types of cancer such as liver, prostate, and bone cancers [PMC8191793]. The downregulation of MIR765 has been shown to inhibit the proliferation, migration, and invasion of non-small cell lung cancer cells [PMC8349552]. Furthermore, MIR765 has been identified as a potential ceRNA (competitive endogenous RNA) for GALNT2 in IgA nephropathy (IgAN) [PMC7719294]. GALNT2 was found to be significantly down-regulated in the peripheral blood mononuclear cells (PBMCs) of IgAN patients and the identified circRNAs were shown to potentially manipulate the expression of GALNT2 through their interaction with MIR765 [PMC7719294]. Overall, these findings highlight the importance of MIR765 in various types of cancer and its potential as a diagnostic marker and therapeutic target.

Genome locations

Gene Ontology annotations

Sequence

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UUUAGGCGCUGAUGAAAGUGGAGUUCAGUAGACAGCCCUUUUCAAGCCCUACGAGAAACUGGGGUUUCUGGAGGAGAAGGAAGGUGAUGAAGGAUCUGUUCUCGUGAGCCUGAA

Taxonomic tree

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2D structure Publications