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MIR497: MIR497 is a microRNA that has been shown to regulate neuronal death following ischemia [PMC4998122]. However, a recent study has identified a new association between MIR497 and seizure-induced damage, making it the first to do so [PMC4998122]. Additionally, studies have demonstrated that MIR497 can sensitize lung cancer cells to cisplatin resistance treatment in an AKT2-dependent manner [PMC8787930]. Furthermore, it has been suggested that LINC00152 acts as a sponge and negatively regulates MIR497 [PMC7011539].
MicroRNAs are small non-coding RNA molecules that play crucial roles in gene regulation. MIR497 specifically has been found to be involved in neuronal death following ischemia [PMC4998122]. This indicates its potential importance in understanding and potentially treating ischemic brain injury. However, the present study is the first to establish an association between MIR497 and seizure-induced damage, expanding our understanding of its role in neurological disorders [PMC4998122].
In addition to its role in neuronal death and seizure-induced damage, MIR497 has also been implicated in lung cancer. It has been shown that MIR497 can sensitize lung cancer cells to cisplatin resistance treatment through an AKT2-dependent mechanism. This finding suggests the potential of targeting MIR497 as a therapeutic strategy for overcoming cisplatin resistance in lung cancer patients [PMC8787930].
Furthermore, LINC00152 has been identified as a negative regulator of MIR497. It acts as a sponge for this microRNA, potentially reducing its availability for gene regulation. This finding highlights the complexity of microRNA regulation and suggests LINC00152 as a potential therapeutic target for modulating the activity of MIR497 [PMC7011539].
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