hsa-mir-4281: Hsa-mir-4281 is a microRNA that has been found to be upregulated in various conditions, including breast cancer [PMC10048937] and myocardial infarction [PMC7248292]. In breast cancer, hsa-mir-4281 was identified as one of the top miRNAs that were upregulated [PMC4867432]. It was subsequently chosen for further validation in a cohort of breast cancer patients and normal controls [PMC4867432]. In myocardial infarction, hsa-mir-4281 was found to be increased compared to controls [PMC7248292]. Additionally, hsa-mir-4281 has been shown to be upregulated in response to treatment with EGCG [PMC5221119]. On the other hand, hsa-mir-4281 has also been found to be downregulated in certain conditions, such as cervical cancer and (pre)cancers in general [PMC5190061]. It has been associated with various functions and pathways, including nucleoside transmembrane transporter activity and nucleobase-containing compound transmembrane transporter activity [PMC7137223], as well as the TNF signaling pathway [PMC7137223]. Overall, hsa-mir-4281 appears to play a role in different diseases and conditions, with its expression levels being regulated depending on the specific context.