hsa-mir-3660: Hsa-mir-3660 is a microRNA that was analyzed in a study on primary open-angle glaucoma (PEXG) [PMC7655255]. Although the C-index value of hsa-mir-3660 was higher than the RNA prognostic biomarker model, the Kaplan-Meier analysis showed that hsa-mir-3660 cannot significantly distinguish between high- and low-risk groups [PMC7655255]. In the study, ten miRNAs were found to be downregulated in PEXG, including hsa-mir-3660 [PMC10000531]. Additionally, six out of twenty selected miRNAs, including hsa-mir-3660, were found to influence the expression of genes involved in protein modification and metabolism [PMC10000531]. The expression level of hsa-mir-3660 was reduced by 13.15% in PEXG compared to the control group [PMC10000531]. Functional analysis revealed that hsa-mir-3660 is involved in ECM receptor interactions through its regulation of LAMA3 gene expression [PMC10000531]. In another study on lung cancer patients living in areas with high levels of radon, a decrease in the expression level of hsa-mir-3660 was observed among other microRNAs [PMC8962319]. Furthermore, five microRNAs including hsa-mir-3660 had low expression levels and were even absent (expression level zero) in more than 20% of tumor tissue samples from lung cancer patients [PMC5912208]. Overall, these studies highlight the potential role of hsa-mir-3660 as a biomarker and its involvement in various biological processes. However, further research is needed to fully understand its functional significance and clinical implications.