bta-mir-874: Bta-mir-874 is a downregulated miRNA that is considered a master regulator in the context of immune genes [PMC9445238]. It has been found to potentially regulate the expression of BCL2A1 [PMC7020904]. Additionally, bta-mir-874 has been shown to directly regulate the expression of PPARα, a transcription factor in the PPAR signaling pathway that is involved in lipid metabolism and fat deposition [PMC5341059]. Bta-mir-874 has also been found to have a high number of target genes, indicating its potential regulatory role [PMC6162677]. The alignment and phylogenetic analysis of bta-mir-874 have shown its conservation between cow, mouse, and megabat [PMC8578396]. Furthermore, bta-mir-874 has been associated with fat levels in beef cattle [PMC8578396]. In summary, bta-mir-874 is a downregulated miRNA that plays a role in immune gene regulation and potentially regulates the expression of BCL2A1. It also directly regulates PPARα and is associated with fat levels. The conservation and evolutionary analysis suggest its importance across different species.