rno-mir-183: Rno-mir-183 is a microRNA that is downregulated in the spinal dorsal horn of rats with neuropathic pain [PMC8914318]. The downregulation of rno-mir-183 is associated with the upregulation of Hdac2 and activation of the TXNIP-NLRP3 inflammasome axis, which leads to an inflammatory response and worsens neuropathic pain [PMC8914318]. Hdac2 reduces the expression of rno-mir-183 by deacetylating histone H4 [PMC8914318]. In a study on thecal hyperandrogenesis, rno-mir-183 was found to be downregulated, suggesting its involvement in this condition [PMC3682887]. Rno-miR-24 and rno-mir-183 were highly expressed in the cystic follicles' theca cells, while rno-miR-31 and rno-miR-96 were present in cumulus granulosa cells [PMC3682887]. In rats treated with DHT, several miRNAs were found to be primarily downregulated, including rno-miR-21, rno-miR-31, and rno-mir-183 [PMC3682887]. Among fourteen miRNAs mapped to ingenuity databases, twelve had experimentally validated targets including rno-mir-183 [PMC3682887]. References: [PMC8914318] - Liang Y et al. (2020) The TXNIP-NLRP3 inflammasome axis mediates spinal dorsal horn pyroptosis in rats with neuropathic pain. J Neuroinflammation. 17(1): 43. [PMC3682887] - Yang Y et al. (2013) Differential expression profiles of microRNAs as potential biomarkers for thecal and granulosa cell tumors. Oncol Rep. 30(1): 311-7.