chi-mir-224: Chi-mir-224 is a microRNA that was found to be significantly downregulated in goats in response to weaning stress, indicating a suppression of cell proliferation activity in post-weaning goats [PMC6687162]. In addition to chi-mir-224, other miRNAs such as chi-miR-99b-3p, chi-miR-143-5p, and chi-miR-10b-5p were also downregulated in response to weaning stress [PMC6687162]. These miRNAs are related to cell proliferation and muscle development [PMC6687162]. Furthermore, the expression profiles of these downregulated miRNAs were found to be highly expressed in muscle tissues of 7-month old Chongming white goats [PMC6687162]. These findings suggest that these miRNAs play important roles in goat muscle development [PMC6687162]. Additionally, other downregulated miRNAs such as chi-miR-199a-5p are involved in cell proliferation, apoptosis, and differentiation [PMC6687162]. The downregulation of muscle development-related miRNAs (chi-miR-206 and chi-miR-133a/b) and potential muscle development-associated miRNAs (chi-miR-99b3p, chi-mir224, chi-miR1435p, and chi-miR10b5p) provides important information on weaning-induced growth inhibition in domestic animals [PMC6687162]. The downregulation of cell proliferation-associated miRNAs (chi-miR99b3p, chi-mir224, chi-MIR1435P) also suggests a repression of post-weaning cell proliferation in goats [PMC6687162].