v27

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Ovis aries (sheep) oar-miR-133 secondary structure diagram

Ovis aries (sheep) oar-miR-133 URS00004883E0_9940

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oar-mir-133: Oar-mir-133 is a cardiac-specific microRNA (miRNA) identified as a key regulator in sheep heart, with a one nucleotide (nt) difference from its human, mouse, and rat counterparts [PMC5557765]. It is the most abundant cardiac-specific miRNA in the sheep heart and is considered a hub miRNA for its predicted regulatory role on the gene MAPK14 [PMC5831392]. Unlike its counterparts in other species, oar-mir-133 is the predominant form found in sheep heart tissue, with other forms such as hsa-/mmu-/rno-miR-133a-3p and -5p and hsa-/mmu-/rno-miR-133b present in much lower counts [PMC5557765]. It is also noteworthy that oar-mir-133 is currently the only cardiac-specific miRNA listed for sheep in miRBase 21 [PMC5557765]. Next-generation sequencing (NGS) techniques have detected high counts of oar-mir-133, highlighting its significant expression level [PMC5557765]. Additionally, oar-mir-133 has been found to be differentially expressed in both hypothalamic and uterine libraries of sheep [PMC8131964], suggesting its involvement in multiple physiological processes. It has been proposed to have a trans relationship with oar_circ_0007178 and may regulate genes such as IGF2 among others [PMC9464909], indicating its potential role in diverse biological pathways.

mRNA interactions total

Genome locations

Gene Ontology annotations

Sequence

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UUGGUCCCCUUCAACCAGCUGU

Taxonomic tree

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This sequence is found in 118 other species

  1. Aedes aegypti (yellow fever mosquito) aae-miR-133
  2. Alligator mississippiensis (American alligator) Ami-Mir-133-P1-v2_3p (mature (guide))
  3. Anolis carolinensis (green anole) Aca-Mir-133-P1-v2_3p (mature (guide))
  4. Anopheles gambiae (African malaria mosquito) aga-miR-133
  5. Apis mellifera ame-miR-133-3p
  6. Ateles geoffroyi (black-handed spider monkey) age-miR-133a
  7. Blattella germanica Bge-Mir-133_3p (mature (guide))
  8. Bombyx mori (domestic silkworm) bmo-miR-133
  9. Bos taurus (domestic cattle) Bta-Mir-133-P1-v2_3p (mature (guide))
  10. Branchiostoma belcheri bbe-miR-133-5p
  11. Branchiostoma floridae Bfl-Mir-133-v2_3p (mature (guide))
  12. Branchiostoma lanceolatum (amphioxus) Bla-Mir-133-v2_3p (mature (guide))
  13. Callithrix jacchus (white-tufted-ear marmoset) cja-miR-133a
  14. Callorhinchus milii (elephant shark) Cmi-Mir-133-P4-v2_3p (mature (guide))
  15. Canis lupus familiaris cfa-miR-133a
  16. Capitella teleta cte-miR-133
  17. Cavia porcellus (domestic guinea pig) Cpo-Mir-133-P1-v2_3p (mature (guide))
  18. Centruroides sculpturatus Csc-Mir-133-P19b_3p (mature (guide))
  19. Cervus elaphus (red deer) cel-miR-133a
  20. Chiloscyllium plagiosum microRNA cpl-miR-133
  21. Chrysemys picta bellii Cpi-Mir-133-P1-v2_3p (mature (guide))
  22. Cochliomyia hominivorax mature cho-miR-133
  23. Cochliomyia macellaria mature cma-miR-133
  24. Columba livia (rock pigeon) Cli-Mir-133-P1-v2_3p (mature (guide))
  25. Culex quinquefasciatus cqu-miR-133
  26. Cyprinus carpio (common carp) ccr-miR-133a-3p
  27. Danio rerio (zebrafish) Dre-Mir-133-P1-v2_3p (mature (guide))
  28. Daphnia magna Dma-Mir-133_3p (mature (guide))
  29. Daphnia pulex dpu-miR-133
  30. Dasypus novemcinctus (nine-banded armadillo) Dno-Mir-133-P1-v2_3p (mature (guide))
  31. Dimorphilus gyrociliatus Dgr-Mir-133_3p (mature (guide))
  32. Dinoponera quadriceps dqu-miR-133-3p
  33. Drosophila ananassae dan-miR-133
  34. Drosophila erecta der-miR-133
  35. Drosophila grimshawi dgr-miR-133
  36. Drosophila melanogaster (fruit fly) dme-miR-133-3p
  37. Drosophila mojavensis dmo-miR-133
  38. Drosophila persimilis dpe-miR-133
  39. Drosophila pseudoobscura dps-miR-133
  40. Drosophila pseudoobscura pseudoobscura (Fruit fly) miRNA FBtr0294465_df_nrg
  41. Drosophila sechellia dse-miR-133
  42. Drosophila simulans dsi-miR-133
  43. Drosophila virilis dvi-miR-133-3p
  44. Drosophila willistoni dwi-miR-133
  45. Drosophila yakuba dya-miR-133
  46. Echinops telfairi (small Madagascar hedgehog) Ete-Mir-133-P1-v2_3p (mature (guide))
  47. Epimenia babai Eba-Mir-133_3p (mature (guide))
  48. Eptatretus burgeri Ebu-Mir-133-P6b-v2_3p (mature (guide))
  49. Equus caballus (horse) Eca-Mir-133-P3-v2_3p (mature (guide))
  50. Euprymna scolopes Esc-Mir-133_3p (mature (guide))
  51. Gadus morhua gmo-miR-133a-3p
  52. Gallus gallus (chicken) gga-miR-133a-3p
  53. Gekko japonicus Gja-Mir-133-P1-v2_3p (mature (guide))
  54. Glossina pallidipes (tsetse fly) Gpa-Mir-133_3p (mature (guide))
  55. Gorilla gorilla gorilla ggo-miR-133a (MIR133A)
  56. Gorilla gorilla (western gorilla) ggo-miR-133a
  57. Haliotis rufescens (red abalone) Hru-Mir-133_3p (mature (guide))
  58. Haplochromis burtoni abu-miR-133a
  59. Heliconius melpomene Hme-Mir-133_3p (mature (guide))
  60. Homo sapiens Hsa-Mir-133-P1-v2_3p (mature (guide))
  61. Hyalella azteca miR-133
  62. Ictalurus punctatus ipu-miR-133a
  63. Ixodes scapularis isc-miR-133
  64. Laevipilina hyalina Lhy-Mir-133_3p (mature (guide))
  65. Lagothrix lagotricha (brown woolly monkey) lla-miR-133a
  66. Lepisosteus oculatus (spotted gar) Loc-Mir-133-P1-v2_3p (mature (guide))
  67. Limulus polyphemus Lpo-Mir-133-P12_3p (mature (guide))
  68. Lineus longissimus Llo-Mir-133_3p (mature (guide))
  69. Lingula anatina Lan-Mir-133_3p (mature (guide))
  70. Lottia gigantea (owl limpet) lgi-miR-133-3p
  71. Loxodonta africana (African savanna elephant) Laf-Mir-133-P1-v2_3p (mature (guide))
  72. Macaca mulatta (Rhesus monkey) Mml-Mir-133-P1-v2_3p (mature (guide))
  73. Macaca nemestrina mne-miR-133a
  74. Magallana gigas (Pacific oyster) Mgi-Mir-133_3p (mature (guide))
  75. Manduca sexta (tobacco hornworm) mse-miR-133
  76. Maylandia zebra (zebra mbuna) mze-miR-133a
  77. Microcaecilia unicolor Mun-Mir-133-P1-v2_3p (mature (guide))
  78. Microcebus murinus (gray mouse lemur) Mmr-Mir-133-P1-v2_3p (mature (guide))
  79. Monodelphis domestica mdo-miR-133a-3p
  80. Monopterus albus Mal-Mir-133-P1-v2_3p (mature (guide))
  81. Mus musculus (house mouse) Mmu-Mir-133-P1-v2_3p (mature (guide))
  82. Nasonia giraulti ngi-miR-133
  83. Nasonia longicornis nlo-miR-133
  84. Nasonia vitripennis nvi-miR-133
  85. Nautilus pompilius Npo-Mir-133-P20_3p (mature (guide))
  86. Neolamprologus brichardi (lyretail cichlid) nbr-miR-133a
  87. Notamacropus eugenii (tammar wallaby) Neu-Mir-133-P1-v2_3p (mature (guide))
  88. Octopus bimaculoides Obi-Mir-133_3p (mature (guide))
  89. Octopus vulgaris (common octopus) Ovu-Mir-133_3p (mature (guide))
  90. Oreochromis niloticus (Nile tilapia) oni-miR-133a
  91. Ornithorhynchus anatinus (platypus) oan-miR-133a-3p
  92. Oryctolagus cuniculus (rabbit) Ocu-Mir-133-P1-v2_3p (mature (guide))
  93. Owenia fusiformis Ofu-Mir-133_3p (mature (guide))
  94. Pan paniscus ppa-miR-133a
  95. Penaeus japonicus miR-133
  96. Phoronis australis Pau-Mir-133_3p (mature (guide))
  97. Platynereis dumerilii (Dumeril's clam worm) Pdu-Mir-133_3p (mature (guide))
  98. Polistes canadensis pca-miR-133-3p
  99. Priapulus caudatus Pca-Mir-133_3p (mature (guide))
  100. Pteropus alecto pal-miR-133a-3p
  101. Ptychodera flava Pfl-Mir-133-v2_3p (mature (guide))
  102. Python bivittatus (Burmese python) Pbv-Mir-133-P1-v2_3p (mature (guide))
  103. Rattus norvegicus (Norway rat) Rno-Mir-133-P1-v2_3p (mature (guide))
  104. Ruditapes philippinarum (Manila clam) Rph-Mir-133_3p (mature (guide))
  105. Saccoglossus kowalevskii sko-miR-133
  106. Saguinus labiatus (red-chested mustached tamarin) sla-miR-133a
  107. Salmo salar (Atlantic salmon) ssa-miR-133a-3p
  108. Sarcophilus harrisii (Tasmanian devil) Sha-Mir-133-P1-v2_3p (mature (guide))
  109. Scyliorhinus torazame (cloudy catshark) Sto-Mir-133-P1-v2_3p (mature (guide))
  110. Sipunculus nudus (marine worm) Snu-Mir-133_3p (mature (guide))
  111. Taeniopygia guttata Tgu-Mir-133-P1-v2_3p (mature (guide))
  112. Tetranychus urticae tur-miR-133-3p
  113. Tetraodon nigroviridis Tni-Mir-133-P1-v2_3p (mature (guide))
  114. Tribolium castaneum (red flour beetle) tca-miR-133-3p
  115. Triops cancriformis tcf-miR-133
  116. Wirenia argentea War-Mir-133_3p (mature (guide))
  117. Xenopus laevis xla-miR-133a
  118. Xenopus tropicalis (tropical clawed frog) xtr-miR-133a
 Relationships

Molecular Relationships

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