rno-mir-15b: Rno-mir-15b is a microRNA that was detected and validated in a study on stroke treated with mild hypothermia [PMC6057705]. The study used RT-PCR to detect the expression of rno-mir-15b and rno-miR-598-3p [PMC6057705]. The expression of rno-mir-15b was found to be significantly decreased at 24 hours after cerebral ischemia, as shown in Figure 2a [PMC6057705]. The study also identified two putative binding sites for miR-15b and miR-16 in the 3'UTR of Faim, suggesting that Faim could be a novel target for these microRNAs [PMC4508667]. Additionally, rno-mir-15b was predicted to target genes involved in the TNF signaling pathway, such as prostaglandin-endoperoxide synthase 2 and Jun proto-oncogene [PMC6377737]. Furthermore, rno-mir-15b was found to be involved in the regulation of the NOD-like proteins response to heat stress by targeting heat shock protein 90 beta family member 1 [PMC6377737]. Overall, these findings suggest that rno-mir-15b plays a role in stroke treated with mild hypothermia and is involved in the regulation of various signaling pathways.