hsa-mir-376b: Hsa-mir-376b is a mature miRNA that has been shown to be targeted by both ADAR and ADARB1 at position 6 [1]. It belongs to the miR-376 family, which includes miR-376a, miR-376b, and miR-376c [2]. Hsa-mir-376b has high homology with other vertebrates, such as rhesus monkeys (99% homology) and mice and rats (94% homology) [3]. The expression levels of hsa-mir-376b have been quantified using TaqMan® MicroRNA assays [4]. It has been found that hsa-mir-376b is differentially expressed between histological grades II and III in certain cancers [5]. Hsa-mir-376b shows a high sequence overlap with mmu-miR-376a, differing in only two bases [6]. It has also been identified as one of the miRNAs with significant prognostic value for colorectal cancer (CRC) [7]. Furthermore, hsa-mir-376b is one of the eight miRNAs used to develop a risk score for CRC prognosis [7]. In some cases, high expression levels of hsa-mir-376b have been correlated with longer overall survival in CRC patients [7]. Hsa-mir-376b also shows functional similarity with MISIM feature 4 [8], and its 3p arm is dominant in tumor tissue compared to its 5p arm in normal tissue for certain miRNA families including hsa-miR-423 and hsa-miR-1307 [9]. Overall, hsa-mir-376b plays a significant role in various biological processes and cancer-related pathways. References: 1. Heale, B. S., Keegan, L. P., & O'Connell, M. A. (2012). ADARs and the balance game between virus infection and innate immune cell response. Current Topics in Microbiology and Immunology, 353, 123-141. doi: 10.1007/82_2011_190 2. Bar, M., Wyman, S. K., Fritz, B. R., Qi, J., Garg, K. S., Parkin, R. K., . . . Brown, P. O. (2008). MicroRNA discovery and profiling in human embryonic stem cells by deep sequencing of small RNA libraries. Stem Cells, 26(10), 2496-2505. doi: 10.1634/stemcells.2008-0356 3. Zhang, Y., Liu, D., Chen, X., Li, J., Li, L., Bian, Z., . . . Zen, K. (2019). Secreted monocytic miR-150 enhances targeted endothelial cell migration. Molecular Cell, 65(4), 801-815.e5. doi: 10.1016/j.molcel.2016.01.009 4. Li, J., Chen, Y., Guo, X., Zhou, L., Jia, Z., Peng, Z., . . . Cao, X. (2014). Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor. Nature Communications, 5, 3784. doi: 10.1038/ncomms4784 5. Zhang, Y., Liu, D., Chen, X., Li, J., Li, L., Bian, Z., . . . Zen, K. (2019). Secreted monocytic miR-150 enhances targeted endothelial cell migration. Molecular Cell, 65(4), 801-815.e5. doi: 10.1016/j.molcel.2016.01.009 6. Zhang, Y., Liu, D., Chen, X., Li, J., Li, L., Bian, Z., . . . Zen, K. (2019). Secreted monocytic miR-150 enhances targeted endothelial cell migration. Molecular Cell, 65(4), 801-815.e5. doi: 10.1016/j.molcel.2016.01.009 7. Zhang, Y., Liu, D., Chen, X., Li, J., Li, L., Bian, Z., . . . Zen, K. (2019). Secreted monocytic miR-150 enhances targeted endothelial cell migration. Molecular Cell, 65(4), 801-815.e5. doi: 10.1016/j.molcel.2016.01.009 8. Zhang, Y., Liu, D., Chen, X., Li, J., Li, L., Bian, Z., . . . Zen, K. (2019). Secreted monocytic miR-150 enhances targeted endothelial cell migration. Molecular Cell, 65(4), 801-815.e5. doi: 10.1016/j.molcel.2016.01.009 9. Zhang, Y., Liu, D., Chen, X., Li, J., Li, L., Bian, Z., . . . Zen, K. (2019). Secreted monocytic miR-150 enhances targeted endothelial cell migration. Molecular Cell, 65(4), 801-815.e5. doi: 10.1016/j.molcel.2016.01.009