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hsa-mir-641: Hsa-mir-641 is a human miRNA that is predicted to have targets in close proximity and functional synergy with its host, according to the hypothesis of an interactome feedback circuitry [PMC3091682]. In a study comparing OA chondrocytes and normal chondrocytes, it was found that hsa-mir-641 was up-regulated in normal chondrocytes compared to OA chondrocytes, along with five other miRNAs (hsa-miR-149*, hsa-miR-582-3p, hsa-miR-1227, hsa-miR-634, and hsa-miR-576-5p) [PMC3495209]. However, one miRNA (hsa-miR-483-5p) was up-regulated in OA chondrocytes [PMC3495209]. These findings suggest that hsa-mir-641 may play a role in the regulation of gene expression in chondrocytes and potentially contribute to the pathogenesis of osteoarthritis. Further research is needed to fully understand the functional significance of these miRNAs and their targets.
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