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rno-mir-34b: Rno-mir-34b, a microRNA, is significantly up-regulated in the small intestine of rats after heat treatment, indicating its involvement in heat stress-induced intestinal epithelial cell apoptosis [PMC7699918]. However, the specific mechanism by which this occurs is still unclear [PMC7699918]. Dysregulation of five miRNAs (rno-miR-214, rno-miR-99a, rno-miR-363*, rno-miR-100, and rno-miR-340–5p) at 24 hours and six miRNAs (rno-mir-34b, rno-miR-500, rno-miR-24-1*, rno-miR-29b, rno-miR-199a-3p, and rno-let-7a) at 48 hours after heat treatment has been observed [PMC5856749]. Bioinformatics databases have predicted SLC4A1 as a potential target gene for several miRNAs, including rno-mir-34b [PMC5748115]. Additionally, quantitative real-time PCR analysis has been conducted to validate changes in the expression levels of six miRNAs, including rno-miR-378, rno-miR-182, rno-miR-21, rno-miR-34a, rno-mir-34b, and rno-miR-34c [PMC4456708].
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