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MIR101-1: MIR101-1 is a microRNA-containing precursor that has been found to decrease significantly in LT and Ar compared to IBA in various brain regions [PMC7848201]. It is one of the miRNA precursors that showed the highest fold-changes in expression [PMC7848201]. MIR101-1 is also included in the top-ranked miRNA expression signatures [PMC9284388]. It has been identified as one of the differentially expressed genes (DEGs) related to Th2 cells and MAIT cells [PMC9380889]. The G-allele of rs11594111 extends the continuous complementary sequence to MIR101-1 from 7 nucleotides to 11 nucleotides [PMC3198095]. However, SUV39H2 mRNA is not predicted to be a target for MIR101-1 [PMC3198095]. In small RNA-seq datasets, MIR101-1 has uniquely aligned read pairs, while its paralogue MIR101-2 does not have any assigned read pairs [PMC6901076]. In Parkinson's disease patients, MIR101-1 has been found to be notably down-regulated along with other miRNAs such as miR-133b, miR218-2, and miR107 [PMC5288660].
References:
[PMC7848201] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848201/
[PMC9284388] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284388/
[PMC9380889] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380889/
[PM3198095] - https://www.ncbi.nlm.nih.gov/pmc/articles/PM3198095/
[PM6901076] - https://www.ncbi.nlm.nih.gov/pmc/articles/PM6901076/
[PMC5288660] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288660/
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