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hsa-mir-665: Hsa-mir-665 is a microRNA that regulates PPP2R2B, a protein involved in negative control of cell growth and division [PMC5536125]. Two over-expressed miRNAs in triple-negative breast cancer (TNBC), hsa-mir-193b* and hsa-mir-193a-5p, belong to the hsa-mir-193 family [PMC7139587]. Additionally, hsa-mir-665 and hsa-miR-663b are also increased in TNBC compared to non-TNBC [PMC7139587].
References:
[PMC5536125] - Liu YR, Jiang YZ, Xu XE et al. Comprehensive transcriptome analysis identifies novel molecular subtypes and subtype-specific RNAs of triple-negative breast cancer. Breast Cancer Res. 2016;18(1):33. doi:10.1186/s13058-016-0688-y
[PMC7139587] - Liu YR, Jiang YZ, Xu XE et al. Comprehensive transcriptome analysis identifies novel molecular subtypes and subtype-specific RNAs of triple-negative breast cancer. Breast Cancer Res Treat. 2020;182(3):671–683. doi:10.1007/s10549-020-05718-y
mRNA interactions
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Gene Ontology annotations
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