bta-mir-374b: Bta-mir-374b is a microRNA that has been found to be upregulated in various studies. It was upregulated in response to Streptococcus agalactiae and Staphylococcus aureus infection in monocyte-derived macrophages and mammary gland tissue [PMC8568169]. In a different study, bta-mir-374b was one of three miRNAs that showed upregulation, while five miRNAs showed downregulation [PMC8568169]. It was also found to be differentially expressed with significant changes in two upregulated miRNAs and two downregulated miRNAs [PMC8568169]. In another study, bta-mir-374b showed significant upregulation in a group with clinical stages of JD infection [PMC8568169]. Additionally, bta-mir-374b was found to have low abundance levels compared to other groups [PMC5662615]. It has been shown that bta-mir-374b targets transcripts involved in signaling pathways regulating pluripotency of stem cells, mTOR signaling, and FoxO signaling [PMC9581129]. Furthermore, bta-mir-374b has been found to have altered expression in the seminal plasma of infertile men compared to fertile men [PMC9581129]. Bta-mir-374b is one of the bovine homologs of hsa-miR-374a-5p [PMC9459146]. In another study, bta-mir-374b was found to be upregulated in the LD of steers and confirmed by RT-qPCR [PMC8993808]. Finally, it was significantly enriched in HS-EVs compared to control-EVs along with other miRNAs [PMC7519046]. References: [PMC8568169] [PMC5662615] [PMC9581129] [PMC9459146] [PMC8993808] [PMC7519046]