hsa-mir-1299: Hsa-mir-1299 is a microRNA that has been found to be down-regulated in the LCC2vsMCF-7 group, as well as in WP compared to CS [PMC7723334] [PMC7488025]. It has also been identified as part of the 9q21.11 deletion peak [PMC7859411]. Hsa-mir-1299 has been shown to bind to multiple mRNA targets [PMC9729703]. Studies have demonstrated that hsa-mir-1299 plays an inhibitory role in tumor cell proliferation, but its potential role in IS has not been addressed [PMC9729703]. Hsa-mir-1299 has also been found to be upregulated in exosomes in the culture medium of the UVA group, along with other microRNAs such as hsa-miR-4513 and hsa-miR-4422 [PMC7719707]. It has been shown that hsa_circ_0002476 and hsa_circ_0063526 can inhibit the expression of hsa-mir-1299 [PMC9659572]. Additionally, hsa-mir-1299 is predicted to be a potential target of circ_SMAD2 and circ-CSPP1 [PMC7890329] [PMC7260814]. Matsha et al. have demonstrated that hsa-mir-1299 is involved in the progression of type 2 diabetes mellitus [PMC8074411]. Furthermore, after statistical correction, hsa-miR-139-5p and hsa-miR200a3p remained significantly differentially expressed between OA patients and controls along with hsa_mir_1299 (p < 0.05) [PMCID: PMC6941326].