bta-mir-497: Bta-mir-497 is a microRNA that has been identified as dysregulated in bovine serum in response to Foot-and-Mouth Disease Virus (FMDV) infection [PMC5384155]. It is one of the 19 miRNAs that were found to potentially target different regions of the FMDV A24 Cruzeiro RNA genome [PMC5384155]. Bta-mir-497 is located on chromosome 19 in the Bos taurus genome [PMC5384155]. In response to FMDV infection, bta-mir-497 was found to be up-regulated, along with other miRNAs such as bta-miR-17-5p, bta-miR-144, and bta-miR-22-5p [PMC5384155]. These dysregulated miRNAs have been previously associated with cellular proliferation or apoptosis [PMC5384155]. Bta-mir-497 was also found to be significantly up-regulated in response to lipopolysaccharide (LPS) stimulation in a different study [PMC7943879]. The expression of bta-mir-497 was increased after acute stress as well [PMC3436641]. The microarray results were validated using mimic bta-mir-497 synthesized by miScript Primer Assays and quantitative RT-qPCR was performed to measure its expression level [PMC3436641]. References: [PMC5384155] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384155/ [PMC7943879] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943879/ [PMC3436641] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436641/