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hsa-mir-765: Hsa-mir-765 is a microRNA that has been identified as part of a novel fulvestrant signaling cascade in prostate cancer [PMC4626151]. This cascade involves the upregulation of hsa-mir-765 by ERb-mediated transcription, which leads to the suppression of HMGA1 protein expression, contributing to the tumor suppressor action of fulvestrant [PMC4626151]. In a study analyzing miRNA expression in prostate cancer, hsa-mir-765 was found to be downregulated and correlated with poor prognosis [PMC8787190]. Another study focused on hepatocellular carcinoma (HCC) found that hsa-mir-765 was one of two miRNAs that affected prognosis in HCC patients [PMC9422102]. Additionally, in melanoma, hsa-mir-765 was identified as the main upregulated miRNA in extracellular vesicles (pEVs) [PMC7706137].
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