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hsa-mir-4709: Hsa-mir-4709 is a microRNA (miRNA) that has been implicated in various biological processes and diseases [PMC7222416]. It has been reported that miRNAs, including hsa-mir-4709, may regulate genes associated with oxidative stress injuries in retinal pigment epithelial (RPE) cells [PMC7222416]. Hsa-mir-4709 is also one of the prognostic target genes in pancreatic ductal adenocarcinoma (PDAC) and has been associated with the opposite trend in PDAC prognosis [PMC6089101]. Additionally, hsa-mir-4709 has been found to be significantly up-regulated in colon cancer and is associated with poor prognosis [PMC7541229]. In a study on colorectal adenocarcinoma (COAD), hsa-mir-4709 was found to be part of a ceRNA regulatory network, where it interacts with lncRNA LINC00115 to regulate the expression of genes such as SIX4, GRAP, NKAIN4, MMAA, and ERVMER34–1 [PMC7541229]. Furthermore, hsa-mir-4709 was identified as one of the optimum prognostic signature DERs (differentially expressed RNAs) in COAD recurrence prediction models [PMC7541229]. Overall, hsa-mir-4709 plays a role in various diseases and biological processes through its regulation of target genes.
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