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Homo sapiens (human) long intergenic non-protein coding RNA 163 (LINC00163) URS00001D6B47_9606

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LINC00163: LINC00163 is a long non-coding RNA (lncRNA) that acts as a tumor suppressor in lung cancer by upregulating the expression of TCF21, thereby inhibiting cancer development [PMC7493716] [PMC8100187]. Methylation analysis has shown that LINC00163 exhibits a time-dependent decrease in methylation, further supporting its role in lung cancer inhibition [PMC7369933]. LINC00163 has also been found to alleviate lung cancer progression by upregulating TCF21 expression [PMC8714324]. In addition to its role in lung cancer, LINC00163 has been implicated in gastric cancer (GC) as well. It acts as a competing endogenous RNA (ceRNA) to inhibit the invasion and metastasis of GC cells by targeting the miR-183/AKAP12 axis [PMC8637188]. Furthermore, LINC00163 expression is lower in metastatic tissues compared to non-metastatic tissues and higher expression is associated with better prognosis in patients with lung cancer [PMC6781732] [PMC6781732] [PMC6781732]. Functional studies have shown that LINC00163 induces TCF21 expression by recruiting ARID1A to the TCF21 promoter, providing insights into the mechanism of lung cancer progression [PMC7959166] [PMC7959166]. Overall, LINC00163 is involved in various aspects of tumor development and progression and may serve as a potential therapeutic target for different types of cancers.

Genome locations

Gene Ontology annotations

Sequence

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CUCACCCUCGAUGGUGCCCUCGACCUGUCCUCCCUCAGCAGCCUGUGGCAUCCAGACCAGUUCGUGGCCCCUAGGAGGGGAAACUGAGUCCCAGCCCCAGGGUCCUCCCUCGGCUUCACUGGGUGCCCCAUGGAGGAGACAGCCAGGGUGUGUCACCUGACAGGCUCACCAGAACCAGCACAGCAGCUGCUGAGUUUUGGCUCCCGGACCCUGGAGCCCCUGCUGCCGAGGCUGGGGAUGGCGGCUCCAGAGGUCAUUCCUCCCCCGGAAGACACACGCUGGCCUUGGGCCAGGGGACCCUCAGCGACGGGGUCACCCCAAUGUUCUGGAGGCUGCGGUUCUGCUUCCUCCUGGGGCUGAGCUGAGCAAGCUCUAGCUCUCGGGCCGAGCGCAAGGAGGGCAGGAGUGAUGUCUCCAACUGUGCUGAGGUCUGCCCUGGGUGCAAGGGCCCUGUGUUUUCAGCGCUGCCGUGUGGCCCAUGGAUGCCCCAGGCCCCUGGACAGUUGAUGCCUGGGGUCCACACUCCUGGACAGGGCUCUGGACAGUUGAUGCCUGGGGUCCACACUCCUGGACAGGCCCCCGGACAGUUGAUUCCUGGGGUCCACACUCCUGGACAGGGCUCUGGUCAGUUGAUGCCUGGGGUCCACACUCCUGGACAGGGCUCUGGUCAGUUGAUGCCUGGGGUCCACACUCCUGGACAGGCCCCUGGACAGUUGAUGCCUGGGGUCCACACUCCUGGACAGGGCUGAGGAGGUGGUGUCCCCAGACUUGCCCCAGCACAGCUGUGGGGGGCACCCGGACACCCGCCCCGGCCUCAGUCUCCCAUCCCAGCUGGCCCUGACACGGGUGCAUGUGAUGCCCUCCUGGUCUUGGCCUCUCAGACCCAGCUCAGCCACGGCCAUCCAGACCCUUGGGCUCCGGUGUCUUCCCAAAGCUCUGAGAAGCACCCCCUUGGGGCAGCCAGACCCCUGACCACCCUCCGAACCUCGGCUGGACUCCCUGUGGCCCAGUCCGGAAGGGUUCUCCUCGGAACAGAGGGCAGAUGAGGCAAGAGUCGGUCCGAGUUCUGCCCUCUGGCACCGGCAGUGCUGUGGAAGGCCCAUGGGGCGGCUCAGUGGUCCCCAGGGACCUCAGCCUUCGGGAAAGUGCAGCAGAGACCUCAAGGCCCCCCACGCUCAGCUAACGUUGCCCUCGCUCAUCCAGAGCACAGCCCGAGCUGCAGGAGGGCCAGGAGGGCAGAUGCUCCACAGCUCGGACAGCAUCCAUAAGACCCGCGUGGAGAAAAUAGCAAAGGCCAGUGUGGAACGGAGAGGACGUGAACGGCGAGUGCUCGGAGAACAAGCACGCCAGCAGCGAACCCAGGGGGACCAGCCCGACAGCCAGUGCGCUGAGACACCGGCCAACGGCAACGCCCCAUCCUCACCGCGAACGCCACUGUGACGCGCUGACAGUGGAUGCGAAUGCGUGACACAGACAGCGAGUGCCAGUGUGACCGUCACGGCUGAUGCUGAGCACUGCACCGACACACCACAGAAUCUGCAGGCCCAGGGCUCAGCUCCUGCUUGCGGGGCGCAGGCCGGCCCCACCGUCCGACGUACAGACCAGCAUGGGCACCUUAGGCCUCUCCACCCUCCUCUGCCCAGAGCCUGCCACCAUCCGUGUUACACAAGAGCCAGGUGCUGCACAGAGAGGCCACGUGCCUUGCCCCAGGCUGCCAGCUCCAGAGAAUGGUCCGGGGACGCCAUGGUCAUCCGGCCCCAGGACUGCUCCUGACCCUCCUGGGACGGAUCCUCCGGGCAGAGAGGGGACGCCGUGGUCAUCCGGCCCCAGGGCUGCUCCUGACCCUCCUGGGACGGAUCCUCCGGGCAGAGAGGGAAUGAAUCACAUUCCGGAUGGUGGCUUCAGGUCAGAAAGCUGUCAGGUCACCCAGGUGCCAUGCGAGCUGCUCCCCGGAGACGGCUUUCGGCCUUGGGUUUAUCACAGCGGCUGUUUUCCGUCUGCCAAGCCAAGCCUGGCUUUCAUCUCCCCUCGCACAACGGUCUGCUUCCUCAGCCUCUGGGCUUAUAGUGGUUUUCUUUUCUACUGUCUGAAAUUGAAUGUUUAGUUCAUCUAUUUUCUAUUCUCUCAUUUAUAAUAAAAACAUUUCAGAUGAGAA

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Expression New Publications