SNORA13: SNORA13 is a small nucleolar RNA (snoRNA) that has been implicated in various biological processes and diseases. In the context of osteosarcoma, the overexpression of SNORA13, along with SNORD3A and SNORA28, has been shown to induce resistance to the chemotherapy drug doxorubicin (Dox) [PMC7349977]. This resistance is mediated through the modulation of genes involved in DNA damage sensing (GADD45A) and DNA repair (MYC), as well as down-regulation of TOP2A [PMC7349977]. The up-regulation of SNORA13, along with its host gene EPB41L4A, has also been observed in Dox-resistant variants derived from different osteosarcoma cell lines [PMC7349977]. In addition to its role in osteosarcoma, SNORA13 has also been found to be up-regulated in various brain regions and is involved in RNA processing and translation regulation [PMC8458545]. Furthermore, SNORA13 has been implicated in doxorubicin resistance in breast cancer cells and is highly expressed in metastatic breast cancer patients [PMC8445368]. The downregulation of SNORA13 has also been observed in certain cancer types [PMC7538898]. Overall, these findings highlight the diverse roles of SNORA13 across different biological processes and diseases.