hsa-mir-204: Hsa-mir-204 is a microRNA that has been studied in various contexts. It has been found that the decreased expression of hsa-mir-204 in patients with inflammatory breast cancer (IBC) is expected to increase the level of the transcriptional regulator high mobility group AT-hook protein 2 (HMGA2) [PMC4289319]. Additionally, the regulation of hsa-mir-204 expression may play a role in controlling clear cell renal cell carcinoma (ccRCC) development through mediating the focal adhesion pathway [PMC7405617]. In patients with breast cancer susceptibility gene BRCA, hsa-mir-204 was found to be downregulated and associated with overall survival [PMC9918521]. In vitro functional analyses have shown that hsa-mir-204 is involved in inhibiting clonogenic growth, migration, and invasion of endometrial carcinoma cells [PMC4918724]. Furthermore, hsa-mir-204 has been identified as one of several microRNAs associated with different stages and types of gastric cancer [PMC4496000]. Overall, these studies highlight the importance of hsa-mir-204 in various cancer types and its potential as a therapeutic target.
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