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Homo sapiens (human) long intergenic non-protein coding RNA 517 (LINC00517) URS00001A2AB5_9606

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LINC00517: LINC00517 is a long non-coding RNA (lncRNA) that has been studied in various contexts. In a competition analysis for endogenous RNAs, LINC00517 was one of four lncRNAs (along with LINC00452, ST7-AS2, and LINC00461) that were validated by reverse transcription-quantitative PCR in independent samples [PMC7499949]. The expression of LINC00517 was found to negatively correlate with the expression of hsa-miR-144 or hsa-miR-137, suggesting regulation by competition and a potential role in the development of triple-negative breast cancer [PMC7499949]. In another study, the expression of LINC00517 was measured using qRT-PCR in ovarian cancer cells before and after treatment with ivermectin. The study identified a sixteen-lncRNA signature that included LINC00517 and showed changes in expression profiles after treatment [PMC7272521]. Furthermore, this study found that these lncRNAs were not only related to ovarian cancer overall survival but also had binding sites with EIF4A3 [PMC7272521]. Additionally, another study identified alterations in various genes including LINC00517 using qRT-PCR before and after treatment with ivermectin in ovarian cancer cells [PMC7993716]. These findings suggest that LINC00517 may play a role in the development and progression of breast and ovarian cancers.

Genome locations

Gene Ontology annotations

Sequence

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AAGCGCCCGCCAGGACAGGCUCCUGGUGGGUUGUAAGGAGAACGGCAGGAAGAAGUGCUCCCAGGAAGCUGCCUAGCCACCGCCACCACCACAGGGUUCCAUCCAACUGACUUAUGGCAUCAGGAGCUUUGAAUUGUCUCAUCUCCAAGACUCUGAAGGUCCUUACAACACUAGCAAUCCCCUUCAUGCCUUAGGGGAUCUCUACAUGAUGUCCUGCUCAGAUGAUGGAAAGCCAGCCCCCUUCCUCUUGCAAACUGGCUUCUUGCACAGUCACCUGGCCUUAGACUAGAACCAUGGCUCUCAAAUUUCAGGGAAAGUAUGAUCAAGCAGUUCAUCAGGAAGCACAAAUGCCACAUGGACAGGGCAAUUCUUUUUCAAGAAGACCCACAGACUUCUCCUGCCUAGGCUCUGAAGAAGCCACAAAAAUCUGUCCUUCCACUAGGCUUUCAGGAGAGAUGAGCCGUCUCCAUUUCCAUCAGUCACUCAGCUCUUCCCCAACACCACAGACAACUGGCCGCCUUGGAGGCUCUUCCAAGUUUCCUGUAGCAGACUCUUUAGUUGUUAUAAUGUUCCAGAAACUGAAGUGGGAAUGGAAGCUAUCAAGUUUUCUGUACUCCAAAAAUUGUCUCCAGCACAUUCCCUGAGAAAGUGUUGCAUCCUUGCCCUGAACACCUUCCAACAGAAUGACUAAGGAAUACUCAAUGCUAGACCAUUCCAGCCUGUUCACCCACCAAGAGGUGGAACUUGUCUGAAGCUACAGGACCACAAUUGACCAUACCCUCCCCUCCUUCUUUGCUUUAUCUUUUUGGAACAUAUUCUGUUUAUUAUUAACAUUUUUAAACUAUGAGACUUAAAGAUAAUCUGUUCUAAGCCCCUAAUCUUGUACAUGACUAAAAAAAAUCACAAGGACAAAUAGAAUGCAUGCACACCAUCACUCUCCUAUCCUCUACCCACAGCAGAGAUCACUAAUCAAUUAAAGCAAUCUUUUCUACUGCACACAGGUGUGGCCUUAAAAUCCUUCUGGACAGAACGCUUCAGGCAGACUUUUCAUAUUUAAUCAUAAACAUAAAUGACAUCAAACAUUAAACCCAUUUGUCAAUCCAGUGUUAAAUGAUGCUAAAGUAGUUUGUGGUAAAACUGGGCCCAUGUCUCCUCUCUCUCAGCUUAUUGACCUUUCUGCUACAUCACAAUGUUGUACUUAUGUUGAAAUGUCACACUUUACAUCUUCUGCAAAUAUUCCCUCUAGGUUUAACUUUUCCAACAAAAUAUCUCAUCAUGUUUUUGUCUUUUCAUUUUUGUUCUUGAGUAAGUAAUACAUUUACUUGUUUCAAACUCAAAGCAAUGUAAAGGUAUACUCGGGGAAGUCAUGCUACCACCCAAGUCUCCAUCCACUUCAUUCCUCCACUUUUAUUAGUUUAUUGUUUAUCCUUCCAAGGUUUCUUUAUGCAAAUACAUGCAAAUCAAAUAUAUAUUCUCAUUUUCUGUGCUGGCCAUACACAAAAUGUAGCAUAUUAUAUAUACUUGUUGUACCUUUCUUUUUUUAACUUAACAAUAUAACCUAGAAAUGGAUUUUUCUCACUUUUUCGUAGGUUUAUAAUCAUACUACUUUUGACAUUUAGGUCAUUUGAAUAAGAUUCAAUCUAUAAGACCUGCCUUCUUAAACCCUGUUUUGGUCCUCUCUGAGAUUCGAUGCCACUAUUUGGCCAGUUAAAACUAAGCGGCCCUUUUUGCUUAAGUUUAAUUAUCCAUGAUCGAUCUUCUUCAAAAUGUAGGUGAAGUUUCUCUACUAUCCAGCACAUGAUAUGGCCAAUGUUUUUAUUAAGAAAAUAAAUUUUAUUAAAGCCACUACAUGAAAUAUUUCUUUUGAUGGACACUAAAAUAAUAAGCAUACAUAAAGUAUCAUAAUAGCUUAAUAAUAAUUCAGUAUUUUGGAGUUGCCAAGUAUAAAACUGGAGGCUUCAGAAUUAAUUUUAAGGAUUGAGCCCUGGUUAUUAGCAGACACAUGUCUGCUUUAAAACUUUGUCCUUUUCACUAUUAGAAAGCCAAAGGCUGCUUUGGCUCUUAGAGCCUUAGUAGAGCCUCAGAAUUGACCCAUUAGGCUAGUCUCUGAUUAAAUGGACCCCAAAGUGUUAGCCUGAACUCUUUUGUUAAUUGCCUUGAGUGAGUUUGCCUAAUCAAAGGAACGUGUGAAACCUCUGAUCUGUAUGGCAGCCUUAAGAUUUCUGAUCUUCAUUAUCUUCUAUAAAAGUACAUCACUUUUGUAUUUUUCAGUUCCUUUUCAAUCCCCUGAUAAGAAUGACCUGUUAAUAGAUAAACUUAGGCACAUUAAAAUUUUAACAAGUUUAUUUGAGCAUUCAGCAAUUCAUGAACCCAGCAGUCUCAGACUACAAGUGGUUCAGCACUCCACUGAGAGGGUGCAAGGGGAAAACUUGUAUAAGGUGUUUGUGGAAGCAAGACAAAGAAAAUAUCUGAUUGAUUUAGGCUGAAAAUCUCUAGUUACAGGUUGGUUAGCAAUUUCUGAUUGGUUAAACUAAAGUUUUAUUUUAGUAUUUAGGUUGAGUUAGGUUUUGGUUUGCUUACAAAGGCACUGGAGCCAUCUCAGCCUAGUGGACUUGAAAUCAAUUAUUAUAAUAGAUCCCCUACCUAAGAAAGCCAGCAUCCCUAAAGGAAAAUAAAUACUGAGGACUUUAUGCAAAGCAAAGAAAUGGAUGUAAAGACGUGGAUCCUCAUUGCCCUCACAAUACUUCUUUUCCUUGAAAAAAGGCUGAGAAUGGAUAAAGAUAAAUUUAGGCACAGUAAGGACAAAGAUAAAGAAUAGCAAGAACUUGUAGCUUGGAUUAUUGAUGCCAGAGAAGUGGAGACCCCAUGUGGAGAAUAUUUUUACCCGUUUCCCACCACUGCUUCCCGGACAGAGAUAAUCUGGGACCCCUGUGAGUAUAGCCCAGCUGGCAACCUUGCCAUAUUUCCAUCCUGCAAGGCUUCAUUCAGGACAGCGCAGGAACUUAUAGGUCAGUCUAAACACUAAACAAGAACAUUAGCCUUAACAACACAAAUUAGUAAUUCAUUUCUUCCUUAUGUAGCUGAGCACUUAAUGAUCCAAAUCUUGGCGACUGAGUUGGGUAAUAGUUCAUUGCUGGAUGACCCAUCUUGACUUUCAAAGUUGCUAUUGUUUUUACAUUAUCCUCAAGUGUUAUCAUUAAGUUGUGAGCAAGACUAAUUUUCUUAAUCAUUCCCAAUCUCCCCAACCAUUUUUCACUGAAUAAUAUCAUCAACAGGCUGCACAAAUUGGACAUCUGAGAUUUAGUUGAAUUAGUAACACCUAAAAGAUCAUUUAUGGCUGCAGCAAUAAGCCUCCCAUUUCAUCUAAUUAGAGAGCAAGAUUAUUUCCCUAAAUCCCCACUAAUAUUUUGAGUUGACAAACAAUGAAGCAAUCCUGAUAAAGUGAAUAAAUGAGUUUCAU

Taxonomic tree

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Publications