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Bos taurus (cattle) microRNA bta-mir-15a precursor URS0000171CD1_9913

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bta-mir-15a: bta-mir-15a is one of the 12 DA miRNAs identified in X and Y sperm [PMC7505075]. It is also one of the 123 mastitis-related miRNAs that are upregulated in cows with mastitis [PMC6107498]. The expression levels of bta-mir-15a and -15b are not significantly different between BLV-infected and uninfected cattle [PMC8432782]. In addition, bta-mir-15a is down-regulated in normalised data but not in un-normalised data [PMC3589390]. It has been suggested that bta-mir-15a may play a role in promoting lactation in mammary epithelial cells of dairy cows [PMC6268530]. The transfection of bta-mir-15a mimics/inhibitor into mammary epithelial cells has been shown to affect the expression of GHR protein and the synthesis of casein, but the mechanisms are still unknown [PMC6268530]. The regulatory relationship between bta-mir-15a and GHR needs to be confirmed [PMC6268530]. Transfection with bta-mir-15a mimics/inhibitor has been done using siPORT NeoFXTM Transfection Agent, with a final RNA concentration of 30 nM for bta-mir-15a mimics/inhibitor/negative control [PMC6268530]. Bovine miR-15a (bta-mir-15a) is located on bovine chromosome 12 between 18887743bp and 18887825bp [PMC6268530]. Bovine mammary epithelial cells transfected with bta-mir-15a mimics show reduced expression levels of GHR protein and casein, as well as decreased cell viability, while transfection with a bta-mir-15a inhibitor increases cell viability [PMC6268530]. The expression of GHR mRNA and protein is negatively regulated by bta-mir-15a [PMC6268530]. The expression of bta-mir-15a is regulated by DNA methylation and is positively correlated with the expression of its target gene CD163 [PMC6993440].

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Gene Ontology annotations


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This sequence is found in 50 other species

  1. Ailuropoda melanoleuca (giant panda) mir-15 microRNA precursor family
  2. Aotus nancymaae miRNA (ENSANAG00000002507.1)
  3. Ateles geoffroyi (black-handed spider monkey) microRNA age-mir-15a precursor
  4. Callithrix jacchus (white-tufted-ear marmoset) mir-15 microRNA precursor family
  5. Canis lupus familiaris (dog) mir-15 microRNA precursor family
  6. Capra hircus (Goat) microRNA mir-15a (ENSCHIG00000009473.1)
  7. Carlito syrichta miRNA (ENSTSYG00000020886.2)
  8. Cavia porcellus (Domestic guinea pig) mir-15 microRNA precursor family
  9. Cebus imitator (Panamanian white-faced capuchin) microRNA 15a (ENSCCAG00000004160.1)
  10. Cercocebus atys miRNA (ENSCATG00000009933.1)
  11. Chlorocebus sabaeus mir-15 microRNA precursor family
  12. Choloepus hoffmanni (Hoffmann's two-fingered sloth) miRNA (ENSCHOG00000015366.1)
  13. Colobus angolensis palliatus (Angola colobus) miRNA (ENSCANG00000007738.1)
  14. Dasypus novemcinctus (nine-banded armadillo) miRNA (ENSDNOG00000034390.1)
  15. Dipodomys ordii (Ord's kangaroo rat) mir-15 microRNA precursor family
  16. Equus caballus (horse) mir-15 microRNA precursor family
  17. Felis catus (domestic cat) mir-15 microRNA precursor family
  18. Fukomys damarensis (Damara mole-rat) mir-15 microRNA precursor family
  19. Gorilla gorilla gorilla ggo-mir-15a (ENSGGOG00000032089.2)
  20. Gorilla gorilla microRNA ggo-mir-15a precursor
  21. Heterocephalus glaber (naked mole-rat) mir-15 microRNA precursor family
  22. Homo sapiens (human) microRNA hsa-mir-15a precursor
  23. Lagothrix lagotricha (brown woolly monkey) microRNA lla-mir-15a precursor
  24. Lemur catta microRNA lca-mir-15a precursor
  25. Macaca mulatta (Rhesus monkey) microRNA mml-mir-15a precursor
  26. Macaca nemestrina microRNA mne-mir-15a precursor
  27. Mandrillus leucophaeus (Drill) miRNA (ENSMLEG00000004472.1)
  28. Microcebus murinus microRNA 15a (ENSMICG00000019256.3)
  29. Mustela putorius furo (Domestic ferret) miRNA (ENSMPUG00000023170.1)
  30. Nomascus leucogenys microRNA 15a (ENSNLEG00000021690.2)
  31. Ochotona princeps miRNA (ENSOPRG00000018090.1, ENSOPRG00000019082.1)
  32. Otolemur garnettii (small-eared galago) miRNA (ENSOGAG00000017565.1)
  33. Ovis aries miRNA (ENSOARG00000024593.1)
  34. Pan paniscus microRNA ppa-mir-15a precursor
  35. Panthera pardus microRNA 15a (ENSPPRG00000014041.1)
  36. Panthera tigris altaica miRNA (ENSPTIG00000002517.1)
  37. Pan troglodytes microRNA ptr-mir-15a precursor
  38. Papio anubis (Olive baboon) mir-15 microRNA precursor family
  39. Pongo abelii (Sumatran orangutan) mir-15 microRNA precursor family
  40. Pongo pygmaeus microRNA ppy-mir-15a precursor
  41. Procavia capensis miRNA (ENSPCAG00000019494.1)
  42. Propithecus coquereli miRNA (ENSPCOG00000011562.1)
  43. Rhinopithecus bieti miRNA (ENSRBIG00000007554.1)
  44. Rhinopithecus roxellana miRNA (ENSRROG00000017782.1)
  45. Saguinus labiatus microRNA sla-mir-15a precursor
  46. Saimiri boliviensis boliviensis (Bolivian squirrel monkey) miRNA (ENSSBOG00000018432.1)
  47. Ictidomys tridecemlineatus Spermophilus tridecemlineatus (thirteen-lined ground squirrel) mir-15 microRNA precursor family
  48. Tupaia belangeri (northern tree shrew) miRNA (ENSTBEG00000017805.1)
  49. Tupaia chinensis (Chinese tree shrew) mir-15 microRNA precursor family
  50. Tursiops truncatus (bottlenosed dolphin) miRNA (ENSTTRG00000022017.1)