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Homo sapiens (human) hsa-miR-221-3p URS0000170CF4_9606

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hsa-mir-221: Hsa-mir-221 is a microRNA that has been studied in various contexts. It is identified by the Taqman microRNA gene expression assay ID number 000524 [PMC6401030]. In oral carcinogenesis, hsa-mir-221, along with hsa-miR-21 and hsa-miR-29c, has been found to target the genes Phosphatase and tensin homolog (PTEN) and DICER1 [PMC6034275]. In lung cancer, hsa-mir-221 is considered a protective factor along with hsa-let-7a, while hsa-miR-137, hsa-miR-372, and hsa-miR-182∗ are nonprotective [PMC4637011]. Hsa-mir-221 has also been found to be up-regulated in endometrial cancer compared to normal tissue [PMC4165582]. In ovarian cancer, the combination of hsa-mir-221 and hsa-miR-1285 has been shown to have prognostic value [PMC4278335]. Hsa-mir-221 is highly associated with kidney renal clear cell carcinoma (KIRC) along with other miRNAs such as hsa-miR21 and lncRNAs such as MALAT1 and TCL6 [PMC6251074]. Abnormal expression of both HSA-MIR 221 and HSA-MIR 222 have been linked to the development of malignant tumors [PMC9917093]. The hub target genes of HSA-MIR 221 are FOS and ESR1 [PMC6171011]. References: [PMC6401030]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401030/ [PMC6034275]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034275/ [PMC4637011]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637011/ [PMC4165582]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165582/ [PMC4278335]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278335/ [PMC6251074]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251074/ [PMC9917093]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917093/ [PMC6171011]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171011/

mRNA interactions 44 total

Genome locations

Gene Ontology annotations

Localisation

Sequence

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Taxonomic tree

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This sequence is found in 51 other species

  1. Alligator mississippiensis ami-miR-221-3p
  2. Anolis carolinensis Aca-Mir-221-P2a_3p (mature (guide))
  3. Bos taurus Bta-Mir-221-P2a_3p (mature (guide))
  4. Canis lupus familiaris Cfa-Mir-221-P2a_3p (mature (guide))
  5. Capra hircus miR-221
  6. Cavia porcellus cpo-miR-221-3p
  7. Cervus elaphus cel-miR-221
  8. Columba livia (rock pigeon) Cli-Mir-221-P2a_3p (mature (guide))
  9. Cricetulus griseus cgr-miR-221-3p
  10. Danio rerio (zebrafish) dre-miR-221-3p
  11. Dasypus novemcinctus (nine-banded armadillo) dno-miR-221-3p
  12. Daubentonia madagascariensis dma-miR-221
  13. Echinops telfairi Ete-Mir-221-P2a_3p (mature (guide))
  14. Equus caballus eca-miR-221
  15. Gadus morhua (Atlantic cod) Gmo-Mir-221-P2a1_3p (mature (guide))
  16. Gallus gallus (chicken) gga-miR-221-3p
  17. Gekko japonicus Gja-Mir-221-P2a_3p (mature (guide))
  18. Gorilla gorilla gorilla ggo-miR-221 (MIR221)
  19. Gorilla gorilla ggo-miR-221
  20. Haplochromis burtoni (Burton's mouthbrooder) abu-miR-221
  21. Latimeria chalumnae Lch-Mir-221-P2a_3p (mature (guide))
  22. Lepisosteus oculatus Loc-Mir-221-P2a_3p (mature (guide))
  23. Macaca mulatta mml-miR-221-3p
  24. Maylandia zebra (zebra mbuna) mze-miR-221
  25. Microcebus murinus mmr-miR-221
  26. Monodelphis domestica (gray short-tailed opossum) mdo-miR-221-3p
  27. Monopterus albus Mal-Mir-221-P2a1_3p (mature (guide))
  28. Mus musculus (house mouse) mmu-miR-221-3p
  29. Neolamprologus brichardi nbr-miR-221
  30. Nomascus leucogenys (northern white-cheeked gibbon) nle-miR-221
  31. Ophiophagus hannah oha-miR-221-3p
  32. Oreochromis niloticus oni-miR-221
  33. Oryctolagus cuniculus ocu-miR-221-3p
  34. Oryzias latipes (Japanese medaka) ola-miR-221
  35. Otolemur garnettii oga-miR-221
  36. Ovis aries miscellaneous RNA
  37. Pan paniscus (pygmy chimpanzee) ppa-miR-221
  38. Pan troglodytes ptr-miR-221
  39. Papio hamadryas pha-miR-221
  40. Pongo pygmaeus (Bornean orangutan) ppy-miR-221
  41. Pundamilia nyererei pny-miR-221
  42. Rattus norvegicus (Norway rat) rno-miR-221-3p
  43. Saimiri boliviensis boliviensis (Bolivian squirrel monkey) sbo-miR-221
  44. Sarcophilus harrisii Sha-Mir-221-P2a_3p (mature (guide))
  45. Sphenodon punctatus (tuatara) Spt-Mir-221-P2a_3p (mature (guide))
  46. Taeniopygia guttata (zebra finch) tgu-miR-221-3p
  47. Takifugu rubripes fru-miR-221
  48. Tetraodon nigroviridis (spotted green pufferfish) tni-miR-221
  49. Tor tambroides miR-221-3p
  50. Xenopus laevis Xla-Mir-221-P2a4_3p (mature (guide))
  51. Xenopus tropicalis (tropical clawed frog) xtr-miR-221
Publications