bta-mir-487b: bta-mir-487b is a microRNA that has been found to be correlated with methane metabolism and several other pathways in the rumen [PMC9378797]. It has the highest number of correlations with different genera and is associated with sugar metabolism, transcription factors, and transporters [PMC9378797]. However, its relationship with bacteria is not well understood yet [PMC9378797]. Interestingly, bta-mir-487b is negatively correlated with Gram-positive strains despite being positively correlated with the peptidoglycan biosynthesis pathway [PMC9378797]. It also shows a strong correlation with a high number of taxa [PMC9378797]. In terms of expression levels, bta-mir-487b is differentially expressed in peak and late lactation in bovine tissue, being higher in late lactation compared to peak lactation [PMC3498112]. Additionally, bta-mir-487b is highly expressed in the fetal stage and other differentiated tissues but not found in bovine calf or adult muscles [PMC3563516]. References: [PMC9378797] - Morgavi DP et al. (2021) Rumen microbiome-host interactions: Insights into the role of microRNAs. Front Microbiol. 12: 637637. doi: 10.3389/fmicb.2021.637637. [PMC3498112] - Li R et al. (2012) Comparative microRNAome analysis of the mammary gland tissues from two breeds of cattle after removal of suckling stress using deep sequencing. PLoS One 7(9): e44587. [PMC3563516] - Li R et al. (2013) Comparative analysis of muscle miRNAs between prenatal development and adulthood reveals miR-483 as a candidate regulating muscle differentiation via IGF-1 signaling pathway. PLoS One 8(5): e62787.