cfa-mir-487b: Cfa-mir-487b is a microRNA that has been studied in the context of canine mitral valve disease (MMVD). In several studies, it has been found that cfa-mir-487b is downregulated in dogs with MMVD, specifically in stages B1/B2 or C/D, compared to stage A dogs [PMC9607079] [PMC4490541] [PMC5533140]. Additionally, when comparing stages B1/B2 and C/D, the expression of cfa-mir-487b was found to be higher in the later stages [PMC9607079]. In dogs with MMVD and mild to moderate cardiac enlargement or congestive heart failure, cfa-mir-487b was also downregulated compared to normal dogs [PMC4964495]. Furthermore, the expression of cfa-mir-487b significantly differed between dogs with congestive heart failure and those with mild to moderate cardiac enlargement [PMC4964495]. Overall, these findings suggest that cfa-mir-487b may play a role in the progression and severity of MMVD. However, further research is needed to fully understand its specific functions and mechanisms in this disease.
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