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Homo sapiens (human) small nucleolar RNA, H/ACA box 29 (SNORA29) secondary structure diagram

Homo sapiens (human) small nucleolar RNA, H/ACA box 29 (SNORA29) URS000014DCD2_9606

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SNORA29: SNORA29 is a small nucleolar RNA (snoRNA) that is involved in RNA modification. In a study comparing DHA-treated samples to control samples, SNORA29 was found to be increased by more than two-fold in the DHA-treated samples [PMC5679375]. SNORA29 is a highly conserved snoRNA that is expressed in a partially processed form, most likely a lariat, in humans [PMC8609340]. It has been shown to mediate rRNA modification despite being expressed at low levels [PMC8609340]. SNORA29 has also been found to be upregulated following traumatic brain injury (TBI) [PMC6044101]. However, its expression in the human brain is significantly decreased compared to other species, possibly due to two human-specific mutations that affect its secondary structure stability [PMC4824147]. The decreased abundance of SNORA29 in the human brain may be caused by these mutations and not by changes in its host gene expression [PMC4824147]. The exact role of SNORA29 and its impact on human-specific cognitive features are still not fully understood [PMC4824147][PMC6984369].

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2D structure Publications