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Homo sapiens (human) TGFB2 antisense RNA 1 (head to head) (TGFB2-AS1) URS0000126BEF_9606

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TGFB2-AS1: TGFB2-AS1 is a long non-coding RNA (lncRNA) that has been found to regulate the expression of certain genes. In a study using MDA-231-siAS1 and MDA-231-siNC cells, transcriptome microarray analysis was performed to identify the genes that are regulated by TGFB2-AS1 and SMARCA4 [PMC9522332]. Another study reported that TGFB2-AS1, along with five other lncRNAs (LINC02678, HOXA10-AS, RHOXF1-AS1, AC010789.1, and LINC01150), is associated with gastric cancer prognosis and somatic mutations [PMC9082950]. Inhibiting the activity of PRC2/EZH2 methyltransferase with a chemical inhibitor called GSK343 resulted in a weak induction of CDH2 mRNA expression and enhanced response to TGF-β. However, the repressive effect of TGFB2-AS1 was relieved by at least 3-fold but not enough to fully revert CDH2 levels to their TGF-β-inducible state [PMC6859500]. These findings suggest that TGFB2-AS1 may play an inhibitory role in the progression of triple-negative breast cancer (TNBC) [PMC9522332]. Furthermore, TGFB2-AS1 has been shown to have both positive and negative effects on gene expression [PMC6859500]. Specific primers were synthesized for amplifying TGFB2-AS1 fragments using PCR [PMC6859500]. Overall, these studies provide insights into the role of TGFB2-AS1 in gene regulation and its potential implications in cancer progression.

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