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Homo sapiens (human) KLF3 antisense RNA 1 (KLF3-AS1) URS00001229EA_9606

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KLF3-AS1: KLF3-AS1 is a long noncoding RNA (lncRNA) that has been studied in various contexts. In an in vitro model of osteoarthritis (OA) using rat articular chondrocytes, extracellular vesicles (EVs) carrying KLF3-AS1 were found to suppress apoptosis of chondrocytes induced by the proinflammatory cytokine interleukin 1β (IL-1β) [PMC8102683]. KLF3-AS1 acts as a competing endogenous RNA (ceRNA) by sponging miR-138-5p, which in turn regulates the expression of Sirt1 and pyroptosis of cardiomyocytes, as well as the progression of myocardial infarction [PMC6918658]. Human bone marrow-derived mesenchymal stem cell (BM-MSC)-derived exosomes also contain KLF3-AS1, which can bind to miR-206 and affect the regulation of G protein-coupled receptor kinase interacting protein 1 (GIT1) [PMC9445804]. In a study on head and neck squamous cell carcinoma patients, KLF3-AS1 was included in a risk score calculation formula [PMC9780454]. Loss of KLF3-AS1 leads to high levels of miR-185-5p and downregulation of KLF3 [PMC9609348]. Furthermore, overexpression of KLF3-AS1 has been shown to inhibit invasion, migration, and epithelial-mesenchymal transition in gastric cancer cells while promoting chemosensitivity to cisplatin [PMC8567101]. These studies highlight the diverse roles that KLF3-AS1 plays in different cellular processes and diseases.

Targeting miRNAs 3 total

According to LncBase, this RNA is targeted by the following miRNAs:

Genome locations

Gene Ontology annotations

Sequence

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AGCCGCCACACUUUCCCAAGCCCGCAGGCGCCCCCCCCAACACCAGCGCUGCACCCCCGACCCAUUCCCCGCGGCCCCCUCCAGGAGAAAAAAUGAAACCAGACUGGCCGAGGAGGGGGGCGGCAGGGACCAGGGUGCGGAGCAGAGGUGAGGGAGACGGGACUUACUUUGCGAGGCGCGGUGCAGGGCGCCGCCGACGAGAAAUAAAGGCCCCGAUACGGGCUGCCUGGAGCCCCCCGAGCGCAGCAAUGUCAGGGCUCCAGUCCGGGCGGCGUUGGCGGCCGCAGGGGACGGGGACGGGCGCGCGUGCGGCGGGCGCUCUCGCUGCGCUCCGGCUCGGGCCCCGGCUCCGCGCGGCUCCGCUCCUGGCUCCCCUCUGGCUCCUGGCACCAACUCCGGGCAGUCACAUGACGCCGGCGCCGCUCGCUCUGCGAGCCUCCCGGGGCUGGCGGGAGAAUAACUUGUCUGACUACCAGUAUUCUUGGAUGCAGAAGUGCUGAAGAUGAGCACACACACGUACGGAGAAUUUCUGGAGAAUUCAGCUGCUCAGAACAAGAACUGAGAUCCAGAGAGAUGAUGACUUUGCCCAUAGACCAAACAAAGAAAUACAUGUUUCAGUCCUGUGUCCUCCUGCUAUGUGUGUCCGGAAUUGGUGGGUUCUUGGUCUCACUGACUUCAAGAAUGAAGCUGCGGACCCUCGCGGACCGUGUGUGAAUGCCUGCUCUGUGAGCCCUCAGAAUCUACUGGCUGAAUGAGUGCGUGGAGGAAAUGUGCUCAGAGCUGCUGUGUGUCAUCCUGUGUUUGAAGUGCUCCUGCAGCUAUCAUUCAUCCAGUUAAGAAUUUGAAGAAGUGUGUGCACAAAGACGGAGUCUCACUCUGUUGCCCAGGCUGGAGUGCAGUGGCACAAUCUCGGCUCACUGCAACCUCUACCUCCUGGAUUCAAGCGGUUUUCCUGCCUCAGCCUCCAGAGUAACAGGGAUUACAGGCAUACUCCACCUUGCCCUGCUGAUUUUGUAUUUUUAGUAGAGACAAGAGUUUCACCAUGUUGGCCAGGCUGGUCUUGAACUCCUGACCUCAAGUGAUCCACUGCCUCAGCCUCCCAAAGUGCUGGGAUUAUAGGCGUGAGCCACUGCGCCUGGCCAAAUGCUCUACUUUUUAAUCAAUGUUUUCCAAAAUAGGGAUUUUUGCUAUGUGCUUUAGAAAUUAGAGAACAAACGGUGAUAAUAUAUGCUAAACUUAAAAUUAGUAUGCCUCCUUUUAUAGACAACAAGAACUUUGUCACUUCCCAGUUUGUCUUGUCAUUCAGGAGGCUCAGAGCUACGAUCUGUGCCCACUCGUGCUGCCUCUUCUUAACUUUGAUUUCCUGAAGCAGCGAUUUCAUCUCCGUUUCCCCUCAUCACCUGUUCUUUUAACUGUUUAAAAACAGCAUUACAUGUUGUUGCAAGUGGCCUCAAAUUCUUUUUGGUAGAAGGGAAAUUGUAAUCCAUGAGAAGAAAAAAAUUUUCCUAACUAUUCUCAGGUGUGUUUAAGGGCUGCAUUCCAUGAUGCUAUCAGUGCCUUCUUUCAGCUCACAGGAUAUCGGCCAUGUUAAUGAGUCUGAUGUUGCUAGUAUCACAGGCACCGGAAAAUAUGCACAUUAUGCUGGAGCAUUAGAAUGCAACAGAAAGAGCCCUGGGCUUGGAGUAUGCAGAACUGGUUCUUGUUACAACUCCUCUUACUAGUGGGCUCUGGAAGAAAACACAUUGAAUUCAUGAUCAUGGUUAACCUUUGGAGAGAGAGAGGAGACCAGGAUGAAGGAGCCAGUCGAAGAUCCUGUUCAAGUGUACACUGAGCCAGCAGGUUCACCAGAAAGCUAUUGAGCGUUUGCUGGAACACAUUAUGCAGGGUGAAUUUCUUCUGGAAUGUUGCCAAGGAUUUUUUAUGCUUCUGUGGCAGGCAUUUCUUGAACAUUGUCAUUUAGCCAAGCAAAGAAGAUUUUCUUAAAGGAUAGAAAAUGUUUAAAAAUUUUUGUUUGUUUGAAGAUAGGUUAAAUGGCUAUAUGAUCUCAGGAUAAGACAGAGAAAAUCACUUAUUUCUCUAAGUGAUCUGAUUAGGUUAGUGAUGUUUUGCCUUUAAACAGAUUCAUCAUUAUUCCUAAAGUAUUGCUGUAUUAAUACUGUCUUCUAGAAAGUAUCCACCAGUGCCUACUUUUCUUCGAUAUCAUUAGCUGUUUUUCGAAACUGAAUUUGCUCUUCAGAGAUUUCUCAUAUGUUUGCGUAUAAGGAACUACUGGUAAUAGCCAAGAAAAUUUGGAGGUGCAGAGAACAUGCUGAAACAGAAUUUUUCACUUUCAAUUCUAGAACUAUGCCAUAAAAAAAAAGGAAAAUGU

Taxonomic tree

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Publications