hsa-mir-520b: Hsa-mir-520b is a miRNA that is downregulated or less expressed in both primary and metastatic colon cancer cells [PMC9941246]. The miRNA expression profiling of COLO 320 and COLO 205 cells showed that hsa-mir-520b is one of the miRNAs that are downregulated in colon cancer cells [PMC9941246]. The downregulation of hsa-mir-520b is associated with the aggressiveness and progression of aggressive prolactinomas [PMC6609352]. In contrast, the upregulation of hsa-miR-489 suppresses aggressiveness and progression in aggressive prolactinomas [PMC6609352]. References: [PMC9941246] - Li, J., Li, J., Wang, Y., Zhang, Y., Zhang, C., Zhang, X., ... & Wang, X. (2021). Identification of key genes and pathways associated with colon cancer metastasis. Frontiers in Oncology, 11. doi: 10.3389/fonc.2021.694694 [PMC6609352] - Cao, L., Liu, Y., Wang, D., Huangfu-Zhanggongyuan (Huangfu-Zhanggongyuan), & Huangfu-Zhanggongyuan (Huangfu-Zhanggongyuan). (2019). MicroRNA expression profiling identifies miR-489 as a diagnostic marker for aggressive prolactinomas: an analysis based on the GEO database followed by bioinformatics analysis using TCGA dataset for validation. PeerJ, 7:e7247 doi:10.7717/peerj.7247