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Homo sapiens (human) ZNF197 antisense RNA 1 (ZNF197-AS1) URS00000E1A0E_9606

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ZNF197-AS1: ZNF197-AS1 is a long non-coding RNA (lncRNA) that has been identified as a significant prognostic marker in various studies [PMC10047351] [PMC6601370] [PMC8283003] [PMC8158160] [PMC8554333] [PMC9716751] [PMC9531154] [PMC9213787]. It is one of the 14 lncRNAs associated with the prognosis of glioblastoma multiforme (GBM) patients in a ceRNA network study, with lower expression levels of ZNF197-AS1 being associated with a shorter lifespan in GBM patients compared to those with higher levels [PMC6601370]. ZNF197-AS1 has also been found to be associated with drug sensitivity, as its expression was positively correlated with the IC50 values of Nelarabine, ZM-336372, cyclophosphamide, and dexamethasone Decadron in cancer cells [PMC8283003]. In addition, ZNF197-AS1 has been identified as one of the m6A-related prognostic lncRNAs associated with breast cancer (BRCA), and its expression was found to be downregulated in BRCA samples compared to normal breast samples [PMC8554333]. Furthermore, ZNF197-AS1 has been shown to be affected by hsa-miR-92a-1-5p and can influence the expression of BCAR1 through competitive combination in breast cancer cells [PMC8158160]. Overall, these studies highlight the potential role of ZNF197-AS1 as a prognostic marker and its involvement in drug sensitivity and molecular interactions in various cancers.

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