hsa-mir-3157: hsa-mir-3157 is a microRNA that is negatively correlated with claudication distance [PMC8948757]. It has been reported to be upregulated in chronic lymphocytic leukemia (CLL) cells compared to normal B cells [PMC8948757]. The miRNA denoted miR pot.42 in supporting Table S5 was deposited in miRBase as hsa-mir-3157 [PMC3411711]. The editing of hsa-mir-3157, although occurring in only two out of 44 samples, led to a shortened progression-free survival (PFS) and should be further investigated in larger cohorts [PMC7280959]. In CLL samples, hsa-mir-3157 and hsa-miR-6503 were found to be edited within the seed region, which resulted in the prediction of many different mRNA targets [PMC7280959]. Among the 28 target genes significantly correlated with pancreatic ductal adenocarcinoma (PDAC) overall survival (OS), only one target gene of hsa-mir-3157 was significantly associated with PDAC OS [PMC6089101]. Hsa-mir-3157 was found to have overlapping target genes with other miRNAs such as hsa-mir-4709, hsa-mir-501, hsa-mir-30e, and hsa-miR-126 [PMC6089101]. Hsa-mir-3157 is one of the 11 prognostic miRNAs used for constructing a prognostic signature for PDAC. It has a negative coefficient (-0.575) in the risk score formula used for calculating the risk score associated with PDAC prognosis [PMC6089101]. Among these 11 prognostic miRNAs, five including hsa-miR-4521 and hsa-miR5091 have not been previously investigated for their functional roles in cancer [PMC6089101].