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Homo sapiens (human) small nucleolar RNA, H/ACA box 57 (SNORA57) secondary structure diagram

Homo sapiens (human) small nucleolar RNA, H/ACA box 57 (SNORA57) URS00000CC074_9606

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SNORA57: SNORA57 was initially identified as a guide RNA for pseudouridylation of position 1004 in human 18S rRNA [PMC8522698]. However, it was found to be nonfunctional on endogenous yeast 18S rRNA, possibly due to sequence divergence [PMC8522698]. Nevertheless, a yeast optimized version of SNORA57 induced pseudouridylation of position 947 in yeast 18S rRNA [PMC8522698]. When human SNORA57 was expressed in yeast cells, pseudouridylation of position 947 in yeast 18S rRNA was not detected [PMC8522698]. Therefore, a yeast optimized version of SNORA57 was created and tested on yeast 18S rRNA, which lacks pseudouridine at the equivalent position [PMC8522698]. It was demonstrated that the 3' terminal pseudouridylation pocket in SNORA57 can mediate pseudouridylation of positions in vertebrate 18S rRNA [PMC8522698]. SNORA57 is overexpressed in A33-Exos and enriched in Ep-CAM-Exos [PMC7461500]. Logistic regression analysis identified SNORA57 as one of the biomarkers offering the highest accuracy for diagnosis [PMC8639909]. Disruption of SNORA57 accumulation abolished Ψ1045 and Ψ1046 synthesis in the 18S rRNA [PMC8763049]. Additionally, downregulated genes included Mapt7d2 and Snora73a among others [PMC9025840].\

mRNA interactions 1 total

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2D structure Publications