Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) microRNA hsa-mir-33a precursor URS00000CBE63_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

hsa-mir-33a: Hsa-mir-33a is a microRNA that has been found to play a role in various types of cancer, including glioblastoma, hepatocellular carcinoma (HCC), prostate cancer, lung adenocarcinoma, and endometrial cancer [26][27][45][46][PMC9200351][PMC8843861][PMC8615810][PMC9789638][PMC8257864]. It has been shown to regulate the expression of neuropilin-2, inhibiting glioblastoma cell migration [26]. Depletion of hsa-mir-33a is associated with tumorigenesis and poor prognosis in HCC patients [27]. However, there is no evidence in the provided context to support the claim that hsa-mir-33a can interfere with the cisplatin resistance of HCC cells [28]. In liver cancer, miRNAs related to hsa-mir-33a are enriched in fatty acid synthesis and metabolism pathways [PMC8843861]. Hsa-mir-33a has also been found to be dysregulated in HIV patients and may be involved in lipid metabolism [PMC8615810]. In a study on endometrial cancer progression, hsa-mir-33a was identified as a hub gene in ceRNA networks [PMC9200351]. The gene body of SREBF2, including the hsa-mir-33a locus, was found to be hypomethylated and may contribute to the down-regulation of SREBF2 expression [PMC9789638]. Hsa-mir-33a is also involved in the regulation of MAP4K3 expression in gestational diabetes mellitus (GDM) [PMC8257864]. Overall, hsa-mir-33a has been implicated in various biological processes and diseases through its regulation of target genes.

MIR33A: MIR33A is a microRNA that has been studied in relation to ABCA1 protein levels in a MO cohort [PMC5085653]. The relative expression of MIR33A was found to be inversely correlated with ABCA1 protein levels [PMC5085653]. However, it is still unclear whether MIR33A affects plaque development by influencing endothelial cell function, as further evidence is needed [PMC8579465]. Additionally, the combinatory utilization of curcumin and a control sequence of MIR33A did not show any significant difference compared to the use of curcumin alone [PMC7401289].

Genome locations

Gene Ontology annotations


Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

This sequence is found in 5 other species

  1. Gorilla gorilla gorilla ggo-mir-33 (ENSGGOG00000030994.2)
  2. Gorilla gorilla microRNA ggo-mir-33 precursor
  3. Myotis brandtii microRNA mir-33
  4. Pan paniscus microRNA ppa-mir-33 precursor
  5. Pan troglodytes microRNA ptr-mir-33a precursor